ArticleDevelopmental biology2009
Bicaudal C and trailer hitch have similar roles in gurken mRNA localization and cytoskeletal organization.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- P-body-like condensates in the germline.Seminars in cell & developmental biology · 2024Review
- Germ Granules in Animal Oogenesis.Journal of developmental biology · 2022Review
- Elucidation of the RNA-granule inducing sodium azide stress response through transcriptome analysis.Genomics · 2020Article
- Modeling Renal Disease "On the Fly".BioMed research international · 2018Review
- Review
- Zfrp8 forms a complex with fragile-X mental retardation protein and regulates its localization and function.Developmental biology · 2016Article
- BICC1 expression is elevated in depressed subjects and contributes to depressive behavior in rodents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.The Journal of clinical investigation · 2014Article
- The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline.Development (Cambridge, England) · 2014Article
- Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like.Molecular and cellular biology · 2013Article
- Article
- Effect of genetic variant in BICC1 on functional and structural brain changes in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification.Biology open · 2012Article
- The Bic-C family of developmental translational regulators.Comparative and functional genomics · 2012Article
- New insights into the regulation of RNP granule assembly in oocytes.International review of cell and molecular biology · 2012Review
- A functional genomic screen in planarians identifies novel regulators of germ cell development.Genes & development · 2010Article
- Loss of Bicc1 impairs tubulomorphogenesis of cultured IMCD cells by disrupting E-cadherin-based cell-cell adhesion.European journal of cell biology · 2010Article
- Knockdown of bicaudal C in zebrafish (Danio rerio) causes cystic kidneys: a nonmammalian model of polycystic kidney disease.Comparative medicine · 2010Article
- Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development.PLoS pathogens · 2010Article
- Genome-wide analysis of mRNA decay patterns during early Drosophila development.Genome biology · 2010Article
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2 authors.
Funding
Abstract
Bicaudal C and trailer hitch are both required for dorsoventral patterning of the Drosophila oocyte. Each mutant produces ventralized eggs, a phenotype typically associated with failure of the oocyte to provide a dorsalization signal--the Gurken protein--to the follicle cells. Bicaudal C and trailer hitch are both implicated in post-transcriptional gene regulation. Bicaudal C acts in recruiting a deadenylase to specific mRNAs, leading to translational repression. The role of trailer hitch is less well defined, but mutants have defects in protein secretion, and show aberrant distribution of an endoplasmic reticulum exit site marker whose mRNA is associated with Trailer hitch protein. We show that Bicaudal C and trailer hitch interact genetically. Mutants of these two genes have shared defects in localization of gurken and other anteriorly-localized mRNAs, as well as altered microtubule organization which may underlie the mRNA localization defects. Bicaudal C and trailer hitch mutants also share a syndrome of actin-related abnormalities, including the formation of ectopic actin cages near the anterior of the oocyte. The cages sequester Gurken protein, blocking its secretion and thus interfering with signaling of the follicle cells to specify dorsal fate.
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