ArticleBiophysical journal2009
Low energy defibrillation in human cardiac tissue: a simulation study.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- Termination of figure-of-eight reentry via resonant feedback pacing.Frontiers in network physiology · 2025Article
- Electrical Stimulation for Low-Energy Termination of Cardiac Arrhythmias: a Review.Cardiovascular drugs and therapy · 2023Review
- A smoothed boundary bidomain model for cardiac simulations in anatomically detailed geometries.PloS one · 2023Article
- An in-silico assessment of efficacy of two novel intra-cardiac electrode configurations versus traditional anti-tachycardia pacing therapy for terminating sustained ventricular tachycardia.Computers in biology and medicine · 2021Article
- Computational Model for Therapy Optimization of Wearable Cardioverter Defibrillator: Shockable Rhythm Detection and Optimal Electrotherapy.Frontiers in physiology · 2021Article
- Phase Entrainment of Induced Ventricular Fibrillation: A Human Feasibility and Proof of Concept Study.Journal of atrial fibrillation · 2019Article
- Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac Electrophysiology.Bulletin of mathematical biology · 2019Article
- A Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atrium.BioMed research international · 2015Article
- Regional cooling facilitates termination of spiral-wave reentry through unpinning of rotors in rabbit hearts.Heart rhythm · 2012Article
- Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function.American journal of physiology. Heart and circulatory physiology · 2010Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
We aim to assess the effectiveness of feedback-controlled resonant drift pacing as a method for low energy defibrillation. Antitachycardia pacing is the only low energy defibrillation approach to have gained clinical significance, but it is still suboptimal. Low energy defibrillation would avoid adverse side effects associated with high voltage shocks and allow the application of implantable cardioverter defibrillator (ICD) therapy, in cases where such therapy is not tolerated today. We present results of computer simulations of a bidomain model of cardiac tissue with human atrial ionic kinetics. Reentry was initiated and low energy shocks were applied with the same period as the reentry, using feedback to maintain resonance. We demonstrate that such stimulation can move the core of reentrant patterns, in the direction that depends on the location of the electrodes and the time delay in the feedback. Termination of reentry is achieved with shock strength one-order-of-magnitude weaker than in conventional single-shock defibrillation. We conclude that resonant drift pacing can terminate reentry at a fraction of the shock strength currently used for defibrillation and can potentially work where antitachycardia pacing fails, due to the feedback mechanisms. Success depends on a number of details that these numerical simulations have uncovered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.