ArticleBiophysical journal2009
Nanoelectromechanics of methylated DNA in a synthetic nanopore.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- Combined Effects of Methylated Cytosine and Molecular Crowding on the Thermodynamic Stability of DNA Duplexes.International journal of molecular sciences · 2021Article
- A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences.Biochemistry · 2020Article
- Microfluidic epigenomic mapping technologies for precision medicine.Lab on a chip · 2019Review
- Cytosine methylation of mitochondrial DNA at CpG sequences impacts transcription factor A DNA binding and transcription.Biochimica et biophysica acta. Gene regulatory mechanisms · 2019Article
- DNA Methylation Detection Using Resonance and Nanobowtie-Antenna-Enhanced Raman Spectroscopy.Biophysical journal · 2018Article
- Optical Trapping Nanometry of Hypermethylated CPG-Island DNA.Biophysical journal · 2017Article
- Hydroxymethyluracil modifications enhance the flexibility and hydrophilicity of double-stranded DNA.Nucleic acids research · 2016Article
- Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability.Nature communications · 2016Article
- Identifying DNA methylation in a nanochannel.Science and technology of advanced materials · 2016Article
- Article
- Challenges in DNA motion control and sequence readout using nanopore devices.Nanotechnology · 2015Review
- Designing DNA interstrand lock for locus-specific methylation detection in a nanopore.Scientific reports · 2013Article
- Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics.Nature nanotechnology · 2013Review
- An electro-hydrodynamics-based model for the ionic conductivity of solid-state nanopores during DNA translocation.Nanotechnology · 2013Article
- Solid-State and Biological Nanopore for Real-Time Sensing of Single Chemical and Sequencing of DNA.Nano today · 2013Article
- Incorporation of a viral DNA-packaging motor channel in lipid bilayers for real-time, single-molecule sensing of chemicals and double-stranded DNA.Nature protocols · 2013Article
- Detection and quantification of methylation in DNA using solid-state nanopores.Scientific reports · 2013Article
- Mapping recently identified nucleotide variants in the genome and transcriptome.Nature biotechnology · 2012Review
- Nanopores: A journey towards DNA sequencing.Physics of life reviews · 2012Review
- Impact of methylation on the physical properties of DNA.Biophysical journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Methylation of cytosine is a covalent modification of DNA that can be used to silence genes, orchestrating a myriad of biological processes including cancer. We have discovered that a synthetic nanopore in a membrane comparable in thickness to a protein binding site can be used to detect methylation. We observe a voltage threshold for permeation of methylated DNA through a <2 nm diameter pore, which we attribute to the stretching transition; this can differ by >1 V/20 nm depending on the methylation level, but not the DNA sequence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.