ArticleDrug and alcohol dependence2009
Effects of cocaine esterase following its repeated administration with cocaine in mice.
Article in Drug and alcohol dependence, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose.Scientific reports · 2017Article
- Future pharmacological treatments for substance use disorders.British journal of clinical pharmacology · 2014Review
- Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.The Journal of pharmacology and experimental therapeutics · 2012Article
- Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Cocaine esterase-cocaine binding process and the free energy profiles by molecular dynamics and potential of mean force simulations.The journal of physical chemistry. B · 2012Article
- Cocaine hydrolase gene therapy for cocaine abuse.Future medicinal chemistry · 2012Review
- Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicity.Future medicinal chemistry · 2012Review
- Pharmacokinetic strategies for treatment of drug overdose and addiction.Future medicinal chemistry · 2012Review
- Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction.Future medicinal chemistry · 2012Review
- The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination.The Journal of pharmacology and experimental therapeutics · 2012Article
- Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.Drug and alcohol dependence · 2011Article
- Computational design of a thermostable mutant of cocaine esterase via molecular dynamics simulations.Organic & biomolecular chemistry · 2011Article
- Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats.Psychopharmacology · 2011Article
- PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity.Journal of controlled release : official journal of the Controlled Release Society · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA bacterial cocaine esterase (CocE) produces robust protection and reversal of cocaine toxicity. The aim of this study was to investigate how effectiveness of CocE was changed following its repeated administration together with cocaine.
methodsCocaine toxicity was quantified by measuring the occurrence of convulsions and lethality in mice. Immunologic responses of CocE were determined using ELISA. In the protection experiment, i.v. CocE 0.3mg was given 1min before a lethal dose of i.p. cocaine 180mg/kg. In the rescue experiment, i.v. CocE 0.3mg was given 1min after the occurrence of convulsions elicited by i.p. cocaine 100mg/kg. In both treatment paradigms, four trials were conducted in the same animals with a 2-week interval.
resultsCocE retained its effectiveness to protect or rescue mice during the first two trials and these mice did not show an immune response. In contrast, CocE's effectiveness was gradually reduced in the last two trials, accompanied by 10- and 100-fold increases in anti-CocE antibody titers. Nevertheless, effectiveness of CocE could be partially recovered by increasing the dose of CocE. In addition, escalating the dose of CocE from the minimum effective dose for repeated administration could also retain CocE's effectiveness longer and slow the production of anti-CocE antibodies.
conclusionsThese results indicate that CocE is a weak antigen and it can maintain its protective and rescuing ability initially against cocaine-induced toxicity. Decreased effectiveness of CocE following repeated use can be partially improved by adjusting the dose and frequency of CocE treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.