ArticleCurrent biology : CB2009
A role for Id2 in regulating photic entrainment of the mammalian circadian system.
Article in Current biology : CB, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 58 citations in OpenAlex.
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- The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorder.Animal cells and systems · 2023Review
- Photic Entrainment of the Circadian System.International journal of molecular sciences · 2022Review
- Targeted Disruption of theInternational journal of molecular sciences · 2021Article
- Article
- Brain transcriptome profile after CRISPR-induced ghrelin mutations in zebrafish.Fish physiology and biochemistry · 2020Article
- Integrated Analysis of Hub Genes and miRNAs in Dilated Cardiomyopathy.BioMed research international · 2020Article
- Inhibitor of DNA binding in heart development and cardiovascular diseases.Cell communication and signaling : CCS · 2019Review
- Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions.Nature communications · 2019Article
- Macromolecular Assemblies of the Mammalian Circadian Clock.Molecular cell · 2017Article
- Remodeling of the cycling transcriptome of the oyster Crassostrea gigas by the harmful algae Alexandrium minutum.Scientific reports · 2017Article
- Disease implication of hyper-Hippo signalling.Open biology · 2016Review
- Impaired Thermogenesis and a Molecular Signature for Brown Adipose Tissue in Id2 Null Mice.Journal of diabetes research · 2016Article
- E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease.Developmental cell · 2015Review
- Cancer/Testis Antigen PASD1 Silences the Circadian Clock.Molecular cell · 2015Article
- Current Update on Synopsis of miRNA Dysregulation in Neurological Disorders.CNS & neurological disorders drug targets · 2015Review
- Correlation of X-ray computed tomography with quantitative nuclear magnetic resonance methods for pre-clinical measurement of adipose and lean tissues in living mice.Sensors (Basel, Switzerland) · 2014Article
- High fat diet rescues disturbances to metabolic homeostasis and survival in the Id2 null mouse in a sex-specific manner.Biochemical and biophysical research communications · 2014Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Inhibitor of DNA binding genes (Id1-Id4) encode helix-loop-helix (HLH) transcriptional repressors associated with development and tumorigenesis [1, 2], but little is known concerning the function(s) of these genes in normal adult animals. Id2 was identified in DNA microarray screens for rhythmically expressed genes [3-5], and further analysis revealed a circadian pattern of expression of all four Id genes in multiple tissues including the suprachiasmatic nucleus. To explore an in vivo function, we generated and characterized deletion mutations of Id2 and of Id4. Id2(-/-) mice exhibit abnormally rapid entrainment and an increase in the magnitude of the phase shift of the pacemaker. A significant proportion of mice also exhibit disrupted rhythms when maintained under constant darkness. Conversely, Id4(-/-) mice did not exhibit a noticeable circadian phenotype. In vitro studies using an mPer1 and an AVP promoter reporter revealed the potential for ID1, ID2, and ID3 proteins to interact with the canonical basic HLH clock proteins BMAL1 and CLOCK. These data suggest that the Id genes may be important for entrainment and operation of the mammalian circadian system, potentially acting through BMAL1 and CLOCK targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.