ArticlePsychiatry research2009
Diffusion tensor imaging of cocaine-treated rodents.
Article in Psychiatry research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- PPAR-gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double-blind randomized controlled pilot trial.Addiction (Abingdon, England) · 2017Trial
- Assessing white matter integrity as a function of abstinence duration in former cocaine-dependent individuals.Drug and alcohol dependence · 2011Trial
- Chronic Cocaine Use and White Matter Coherence: A Diffusion Tensor Imaging Study.Journal of studies on alcohol and drugs · 2023Article
- Strengthened and posterior-shifted structural rich-club organization in people who use cocaine.Drug and alcohol dependence · 2022Article
- Cocaine-induced neural adaptations in the lateral hypothalamic melanin-concentrating hormone neurons and the role in regulating rapid eye movement sleep after withdrawal.Molecular psychiatry · 2021Article
- White matter deficits in cocaine use disorder: convergent evidence from in vivo diffusion tensor imaging and ex vivo proteomic analysis.Translational psychiatry · 2021Article
- Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.PloS one · 2021Article
- Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol.Journal of proteome research · 2019Article
- Regional elevations in microglial activation and cerebral glucose utilization in frontal white matter tracts of rhesus monkeys following prolonged cocaine self-administration.Brain structure & function · 2019Article
- A preliminary longitudinal study of white matter alteration in cocaine use disorder subjects.Drug and alcohol dependence · 2017Article
- Acute White Matter Tract Damage after Frontal Mild Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- Microstructural changes to the brain of mice after methamphetamine exposure as identified with diffusion tensor imaging.Psychiatry research. Neuroimaging · 2016Article
- Altered white matter in cocaine-dependent subjects with traumatic brain injury: A diffusion tensor imaging study.Drug and alcohol dependence · 2015Article
- Effect of cocaine dependence on brain connections: clinical implications.Expert review of neurotherapeutics · 2015Review
- Neurologic complications of illicit drug abuse.Continuum (Minneapolis, Minn.) · 2014Review
- Regionally-specific alterations in myelin proteins in nonhuman primate white matter following prolonged cocaine self-administration.Drug and alcohol dependence · 2014Article
- Chronic cocaine administration causes extensive white matter damage in brain: diffusion tensor imaging and immunohistochemistry studies.Psychiatry research · 2014Article
- Biomarkers for the development of new medications for cocaine dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Review
- Recovering from cocaine: insights from clinical and preclinical investigations.Neuroscience and biobehavioral reviews · 2013Review
- Reduced limbic metabolism and fronto-cortical volume in rats vulnerable to alcohol addiction.NeuroImage · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Studies in cocaine-dependent human subjects have shown differences in white matter on diffusion tensor imaging (DTI) compared with non-drug-using controls. It is not known whether the differences in fractional anisotropy (FA) seen on DTI in white matter regions of cocaine-dependent humans result from a pre-existing predilection for drug use or purely from cocaine abuse. To study the effect of cocaine on brain white matter, DTI was performed on 24 rats after continuous infusion of cocaine or saline for 4 weeks, followed by brain histology. Voxel-based morphometry analysis showed an 18% FA decrease in the splenium of the corpus callosum (CC) in cocaine-treated animals relative to saline controls. On histology, significant increase in neurofilament expression (125%) and decrease in myelin basic protein (40%) were observed in the same region in cocaine-treated animals. This study supports the hypothesis that chronic cocaine use alters white matter integrity in human CC. Unlike humans, where the FA in the genu differed between cocaine users and non-users, the splenium was affected in rats. These differences between rodent and human findings could be due to several factors that include differences in the brain structure and function between species and/or the dose, timing, and duration of cocaine administration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.