ArticleBiological psychiatry2009
Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies.
Article in Biological psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.PLoS genetics · 2010Pooled it
- Modulating reward and aversion: Insights into addiction from the paraventricular nucleus.CNS neuroscience & therapeutics · 2024Review
- The Interaction BetweenFrontiers in psychiatry · 2022Article
- Genome-Wide Association Study of Opioid Cessation.Journal of clinical medicine · 2020Article
- The genetic epidemiology of substance use disorder: A review.Drug and alcohol dependence · 2017Review
- Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence.Drug and alcohol dependence · 2016Article
- The association of proopiomelanocortin polymorphisms with the risk of major depressive disorder and the response to antidepressants via interactions with stressful life events.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Novel gene identified in an exome-wide association study of tanning dependence.Experimental dermatology · 2014Article
- Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy.Scientific reports · 2014Article
- Array-based profiling of DNA methylation changes associated with alcohol dependence.Alcoholism, clinical and experimental research · 2013Article
- Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence.Journal of human genetics · 2012Article
- The genetics of addiction-a translational perspective.Translational psychiatry · 2012Review
- The genetics of the opioid system and specific drug addictions.Human genetics · 2012Review
- Identification of POMC exonic variants associated with substance dependence and body mass index.PloS one · 2012Article
- Genetic and environmental determinants of stress responding.Alcohol research : current reviews · 2012Review
- Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Alcoholism, clinical and experimental research · 2011Article
- Genetics of drug dependence.Dialogues in clinical neuroscience · 2010Review
- [The endogenous opioid system and drug addiction].Annales pharmaceutiques francaises · 2010Review
- Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Article
- Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence.The American journal on addictionsArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundOpioidergic neurotransmission is critical in many, possibly all, forms of substance dependence. Several opioid-system genes have been shown to be associated with substance dependence disorders. The pro-opiomelanocortin gene (POMC) encodes several peptides important for endogenous opioidergic neurotransmission. We tested whether POMC genetic variation affects risk for substance dependence.
methodsFive single nucleotide polymorphisms spanning POMC were examined in independent family and case-control samples. Family-based studies included 854 subjects from 319 African American (AA) families and 761 subjects from 313 European American (EA) families. Each family had a pair of siblings affected with cocaine and/or opioid dependence. Case-control studies included 791 cases (455 AAs and 336 EAs) affected with alcohol, cocaine, and/or opioid dependence and 682 control subjects (199 AAs and 483 EAs).
resultsFamily-based analyses revealed an association of rs6719226 with opioid dependence in AA families and rs6713532 with cocaine dependence in EA families (p = .010-.044). Case-control analyses demonstrated an association of rs6713532 with alcohol or cocaine dependence in EAs (p(allele-wise) = .003-.008). Moreover, the minor allele of rs1866146 was found to be a risk factor for cocaine or opioid dependence in AAs (p(allele-wise) = .010-.017) and for alcohol, cocaine, or opioid dependence in EAs (p(allele-wise) = .001-.003). Logistic regression analyses in which sex and age were considered and population stratification analyses confirmed these findings. Additionally, specific haplotypes increased risk for cocaine dependence (p = .023) in AAs and opioid dependence (p = .012) in EAs.
conclusionsGiven these replicated results, we conclude that variation in POMC confers vulnerability to multiple forms of substance dependence.
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