ArticleBMC systems biology2009
A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation.
Article in BMC systems biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos.The Journal of allergy and clinical immunology · 2019Pooled it
- Article
- Identification of Effective Diagnostic Biomarkers and Immune Cell Infiltration in Atopic Dermatitis by Comprehensive Bioinformatics Analysis.Frontiers in molecular biosciences · 2022Article
- Transcriptomic insight into the translational value of two murine models in human atopic dermatitis.Scientific reports · 2021Article
- Multi-omics-based identification of atopic dermatitis target genes and their potential associations with metabolites and miRNAs.American journal of translational research · 2021Article
- Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis.International journal of molecular sciences · 2020Article
- Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes.Scientific reports · 2019Article
- Gene expression profiling of asthma phenotypes demonstrates molecular signatures of atopy and asthma control.The Journal of allergy and clinical immunology · 2016Article
- Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis.Journal of immunology research · 2016Article
- Article
- MicroRNAs act complementarily to regulate disease-related mRNA modules in human diseases.RNA (New York, N.Y.) · 2013Article
- Limitations and possibilities of low cell number ChIP-seq.BMC genomics · 2012Article
- Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo.The Journal of allergy and clinical immunology · 2012Article
- Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis.Allergy · 2012Article
- Interleukin 7 receptor gene polymorphisms and haplotypes are associated with susceptibility to IgA nephropathy in Korean children.Experimental and therapeutic medicine · 2011Article
- Network properties of complex human disease genes identified through genome-wide association studies.PloS one · 2009Article
- Bridging the gap between systems biology and medicine.Genome medicine · 2009Article
- Can modular analysis identify disease-associated candidate genes for therapeutics?Journal of biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe identification of novel genes by high-throughput studies of complex diseases is complicated by the large number of potential genes. However, since disease-associated genes tend to interact, one solution is to arrange them in modules based on co-expression data and known gene interactions. The hypothesis of this study was that such a module could be a) found and validated in allergic disease and b) used to find and validate one ore more novel disease-associated genes.
resultsTo test these hypotheses integrated analysis of a large number of gene expression microarray experiments from different forms of allergy was performed. This led to the identification of an experimentally validated reference gene that was used to construct a module of co-expressed and interacting genes. This module was validated in an independent material, by replicating the expression changes in allergen-challenged CD4+ cells. Moreover, the changes were reversed following treatment with corticosteroids. The module contained several novel disease-associated genes, of which the one with the highest number of interactions with known disease genes, IL7R, was selected for further validation. The expression levels of IL7R in allergen challenged CD4+ cells decreased following challenge but increased after treatment. This suggested an inhibitory role, which was confirmed by functional studies.
conclusionWe propose that a module-based analytical strategy is generally applicable to find novel genes in complex diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.