ReviewCritical care (London, England)2009
Bench-to-bedside review: ventilatory abnormalities in sepsis.
Review in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of tachypnoea for predicting mortality and identifying sepsis in young infants aged 0-59 days: a systematic review and meta-analysis.BMJ paediatrics open · 2026Pooled it
- The Acid-Base Effects of Albumin in Sepsis: Reconciling the Stewart Physicochemical Approach with the Traditional Buffer-Base Paradigm.Journal of clinical medicine · 2026Review
- Preoxygenation When Standard Approaches Fail: Phenotype-Based Strategies for High-Risk Emergent Intubations.Journal of clinical medicine · 2026Review
- Navigating Heart-Lung Interactions in Mechanical Ventilation: Pathophysiology, Diagnosis, and Advanced Management Strategies in Acute Respiratory Distress Syndrome and Beyond.Journal of clinical medicine · 2024Article
- The accuracy and feasibility of respiratory rate measurements in acutely ill adult patients by GPs: a mixed-methods study.BJGP open · 2022Article
- Respiratory Drive in Patients with Sepsis and Septic Shock: Modulation by High-flow Nasal Cannula.Anesthesiology · 2021Article
- Hemodynamics of the sternocleidomastoid measured with frequency domain near-infrared spectroscopy towards non-invasive monitoring during mechanical ventilation.Biomedical optics express · 2021Article
- Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice.Scientific reports · 2017Article
- Preservation of renal blood flow by the antioxidant EUK-134 in LPS-treated pigs.International journal of molecular sciences · 2015Article
- Respiratory distress in the newborn.Pediatrics in review · 2014Review
- From data patterns to mechanistic models in acute critical illness.Journal of critical care · 2014Review
- Sepsis: Something old, something new, and a systems view.Journal of critical care · 2012Article
- Use of expiratory change in bladder pressure to assess expiratory muscle activity in patients with large respiratory excursions in central venous pressure.Intensive care medicine · 2012Article
- Sepsis: from pattern to mechanism and back.Critical reviews in biomedical engineering · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In septic patients increased central drive and increased metabolic demands combine to increase energy demands on the ventilatory muscles. This occurs at a time when energy supplies are limited and energy production hindered, and it leads to an energy supply-demand imbalance and often ventilatory failure. Problems related to contractile function of the ventilatory muscles also contribute, especially when the clinical course is prolonged. The increased ventilatory activity increases interactions between the ventilatory and cardiovascular systems, and when ventilatory muscles fail and mechanical ventilatory support is required a new set of problems emerges. In this review I discuss factors related to ventilatory muscle failure, giving emphasis to mechanical and supply demand aspects. I also review the implications of changes in ventilatory patterns for heart-lung interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.