Evidence map›Paper›PMID 19216619›Full record

ReviewExpert opinion on biological therapy2009

In vivo tracking of cellular therapeutics using magnetic resonance imaging.

Christoper M Long, Jeff W M Bulte

Abstract readReview
In one paragraph

Review in Expert opinion on biological therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Engineering mRNA CAR-T Cells for Cancer Immunotherapy.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  2. Review
  3. Application of magnetic nanoparticles in cell therapy.Stem cell research & therapy · 2022
    Review
  4. In vivo imaging of nanoparticle-labeled CAR T cells.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  5. Review
  6. Molecular imaging in tracking cancer stem cells: A review.Medical journal of the Islamic Republic of Iran · 2020
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Encapsulated Islet Transplantation: Where Do We Stand?The review of diabetic studies : RDS · 2017
    Review
  12. Article
  13. Sensitivity of susceptibility-weighted imaging in detecting superparamagnetic iron oxide-labeled mesenchymal stem cells: a comparative study.Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society · 2015
    Article
  14. Article
  15. Magnetic resonance imaging of transplanted stem cell fate in stroke.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christoper M LongThe Johns Hopkins University, School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Baltimore, USA.
Jeff W M Bulte

Funding

MR Tracking of Magnetically Labeled Stem Cells in CNSR01NS045062 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2003 to 2013
$4.4M
Developing a CEST Reporter Gene (RMI)R21EB005252 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2005 to 2008
$1.4M
Developing MPI for Non-Invasive and Quantitative Imaging of Stem CellsR01DA026299 · NIDA · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2008 to 2011
$1.3M
MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet CellsR01EB007825 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2007 to 2008
$992k
NIBIB NIH HHS R01 EB007825NIBIB NIH HHS R21 EB005252NIDA NIH HHS R01 DA026299NINDS NIH HHS R01 NS045062
6 · The paper itself

Abstract

backgroundThe success of many cell-based therapies is highly dependent on the accurate delivery, dosing and trafficking of the cellular therapeutic. In vivo magnetic resonance (MR) cell tracking provides a means to non-invasively and longitudinally evaluate these parameters for cellular therapy.

objectiveTo provide an overview of MR cell tracking and how cellular therapeutics might be improved by utilizing this technology.

methodsWe focused on the technologies utilized for stem cell and immunotherapies in preclinical models of disease. RESULTS/

conclusionNew technologies in MR cell tracking will soon take the field beyond preclinical studies and begin to show benefits in clinical trials of novel experimental cell-based therapies.

Indexed as

ImmunotherapyStem Cell TransplantationAnimalsDisease Models, AnimalHumansMagnetic Resonance ImagingNeoplasmsStaining and LabelingStem Cells

Identifiers

PMID19216619
PMCPMC3079243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.