ArticleJournal of natural products2009
Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis.
Article in Journal of natural products, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- A Systemic Review on Nutraceutical Supplements used in the Management of Osteoarthritis.Recent advances in food, nutrition & agriculture · 2024Pooled it
- Zingiberaceae extracts for pain: a systematic review and meta-analysis.Nutrition journal · 2015Pooled it
- A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial.Nutrition journal · 2013Trial
- Article
- Impact of NSAIDs corticosteroids DMARDs biologics and their comparisons with natural products in C-reactive proteins (CRP) linked cardiovascular disorders.Inflammopharmacology · 2025Review
- Pharmacological and immunomodulatory modes of action of medically important phytochemicals against arthritis: A molecular insight.Molecular biology reports · 2024Review
- Zingiber Officinale Roscoe: The Antiarthritic Potential of a Popular Spice-Preclinical and Clinical Evidence.Nutrients · 2024Review
- Nano-platform Strategies of Herbal Components for the Management of Rheumatoid Arthritis: A Review on the Battle for Next-Generation Formulations.Current drug delivery · 2024Review
- QbD-Optimized, Phospholipid-Based Elastic Nanovesicles for the Effective Delivery of 6-Gingerol: A Promising Topical Option for Pain-Related Disorders.International journal of molecular sciences · 2023Article
- Effect of Ginger on Inflammatory Diseases.Molecules (Basel, Switzerland) · 2022Review
- Indigenous Nigeria medicinal herbal remedies: A potential source for therapeutic against rheumatoid arthritis.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Perspective on Improving the Relevance, Rigor, and Reproducibility of Botanical Clinical Trials: Lessons Learned From Turmeric Trials.Frontiers in nutrition · 2021Review
- Essential Oils and Bioactive Components against Arthritis: A Novel Perspective on Their Therapeutic Potential.Plants (Basel, Switzerland) · 2020Review
- Nonvitamin, Nonmineral Dietary Supplement Use in Individuals with Rheumatoid Arthritis.The Journal of nutrition · 2020Article
- Flavonoids and Related Members of the Aromatic Polyketide Group in Human Health and Disease: Do They Really Work?Molecules (Basel, Switzerland) · 2020Review
- Chinese Herbal Medicines for Rheumatoid Arthritis: Text-Mining the Classical Literature for Potentially Effective Natural Products.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- 6-Shogaol Inhibits Advanced Glycation End-Products-Induced IL-6 and ICAM-1 Expression by Regulating Oxidative Responses in Human Gingival Fibroblasts.Molecules (Basel, Switzerland) · 2019Article
- Suppression of colorectal cancer cell growth by combined treatment of 6-gingerol and γ-tocotrienol via alteration of multiple signalling pathways.Journal of natural medicines · 2019Article
- The Natural Product 6-Gingerol Inhibits Inflammation-Associated Osteoclast Differentiation via Reduction of Prostaglandin E₂ Levels.International journal of molecular sciences · 2018Article
- Anti-Inflammatory Effects of the Essential Oils of Ginger (PharmaNutrition · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Ginger (Zingiber officinale) supplements are being promoted for arthritis treatment in western societies on the basis of ginger's traditional use as an anti-inflammatory in Chinese and Ayurvedic medicine. However, scientific evidence of ginger's antiarthritic effects is sparse, and its bioactive joint-protective components have not been identified. Therefore, the ability of a well-characterized crude ginger extract to inhibit joint swelling in an animal model of rheumatoid arthritis, streptococcal cell wall-induced arthritis, was compared to that of a fraction containing only gingerols and their derivatives. Both extracts were efficacious in preventing joint inflammation. However, the crude dichloromethane extract, which also contained essential oils and more polar compounds, was more efficacious (when normalized to gingerol content) in preventing both joint inflammation and destruction. In conclusion, these data document a very significant joint-protective effect of these ginger samples and suggest that nongingerol components are bioactive and can enhance the antiarthritic effects of the more widely studied gingerols.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.