ArticleClinical neuropathology
Atypical teratoid/rhabdoid tumor of the central nervous system in an 18-year-old patient.
Article in Clinical neuropathology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Atypical teratoid/rhabdoid tumor in adults: a systematic review of the literature with meta-analysis and additional reports of 4 cases.Journal of neuro-oncology · 2022Pooled it
- Radiological image features of the atypical teratoid/rhabdoid tumor in adults: a systematic review.Clinical neuroradiology · 2015Pooled it
- How specific is the MRI appearance of supratentorial atypical teratoid rhabdoid tumors?Pediatric radiology · 2013Pooled it
- Hemispherotomy for atypical teratoid rhabdoid tumor-associated drug-resistant epilepsy: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Atypical Teratoid/Rhabdoid Tumor of the Sellar Region in an Elderly Patient: A Case Report and Literature Review.Cureus · 2025Article
- Primary diffuse leptomeningeal atypical teratoid rhabdoid tumor (AT/RT) demonstrating atypical imaging findings in an adolescent patient.Radiology case reports · 2022Article
- Proximal-Type Epithelioid Sarcoma in Skull Base: a Pathological Diagnosis Challenge with Other Intracranial Tumors.Pathology oncology research : POR · 2019Article
- Article
- A Systematic Review of Atypical Teratoid Rhabdoid Tumor in Adults.Frontiers in oncology · 2018Article
- Atypical Teratoid/ Rhabdoid Tumor of Brain: a Clinicopathologic Study of Eleven Patients and Review of LiteratureAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Atypical Teratoid Rhabdoid Tumor: Two Case Reports and an Analysis of Adult Cases with Implications for Pathophysiology and Treatment.Frontiers in neurology · 2017Article
- Atypical teratoid rhabdoid tumour of the spine: report of a case and literature review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2015Review
- Atypical teratoid/rhabdoid tumor in sellar turcica in an adult: A case report and review of the literature.Surgical neurology international · 2014Article
- Clinicopathologic comparison of familial versus sporadic atypical teratoid/rhabdoid tumors (AT/RT) of the central nervous system.Pediatric blood & cancer · 2011Article
- Atypical teratoid/rhabdoid tumors in adults: a case report and treatment-focused review.Journal of clinical medicine research · 2011Article
- Suboccipital Extraspinal Extracranial Atypical Teratoid Rhabdoid Tumor.Journal of neurosciences in rural practiceArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAtypical teratoid/rhabdoid tumors are aggressive neoplasms of the central nervous system occurring mainly in the early childhood and rarely in adults. We described a case of this tumor in an 18-year-old male patient without previous medical history. MATERIAL AND
methodsThe neoplasm was localized in the right frontotemporal area of the brain and was totally excised. The specimen was fixed in formalin and embedded in paraffin. The histological and immunohistochemical features of the neoplasm were assessed, while sequencing analysis as well as interphase fluorescence in situ hybridization (FISH) were performed.
resultsHistological and immunohistochemical analysis demonstrated atypical rhabdoid cells strongly and diffusely positive for EMA and Vimentin as well as focally immunoreactive for SMA and GFAP. Additionally, though no abnormalities detected in the coding sequence of the INI1 gene, interphase FISH studies were consistent with a homozygous deletion of the INI1 gene in the majority of examined nuclei. INI1 immunostaining demonstrated diffuse loss of nuclear INI1 expression in tumor cells. Taken together, the results were consistent with a diagnosis of atypical teratoid/rhabdoid tumor (ATRT).
conclusions26 previous cases of ATRT have been reported in adults, thus far. To our knowledge, this is the eighth case of an ATRT reported in an adult patient having genetic confirmation and the first one in which the tumor is, partly, localized in the right temporal area of the brain. This unusual presentation underlines the necessity of considering this devastating neoplasm in the differential diagnosis of malignant brain tumors of young adults.
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