Evidence map›Paper›PMID 19216068›Full record

ReviewCurrent opinion in biotechnology2009

Biosensing and imaging based on bioluminescence resonance energy transfer.

Zuyong Xia, Jianghong Rao

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 137 citations in OpenAlex.

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  10. Recent advances of semiconducting polymer nanoparticles in in vivo molecular imaging.Journal of controlled release : official journal of the Controlled Release Society · 2016
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zuyong XiaDepartment of Radiology & Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305-5484, USA.
Jianghong Rao
Stanford University · US

Funding

Stanford Nanocharacterization LaboratoryU54CA119367 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2006 to 2010
$19.8M
QD-BRET nanosensors for protease detection and imagingR01CA135294 · NCI · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2008 to 2012
$1.3M
NCI NIH HHS 1R01CA135294-01NCI NIH HHS 1U54CA119367-01NCI NIH HHS R01 CA135294NCI NIH HHS U54 CA119367
6 · The paper itself

Abstract

Bioluminescence resonance energy transfer (BRET) operates with biochemical energy generated by bioluminescent proteins to excite fluorophores and offers additional advantages over fluorescence energy transfer (FRET) for in vivo imaging and biosensing. While fluorescent proteins are frequently used as BRET acceptors, both small molecule dyes and nanoparticles can also serve as acceptor fluorophores. Semiconductor fluorescent nanocrystals or quantum dots (QDs) are particularly well suited for use as BRET acceptors due to their high quantum yields, large Stokes shifts and long wavelength emission. This review examines the potential of QDs for BRET-based bioassays and imaging, and highlights examples of QD-BRET for biosensing and imaging applications. Future development of new BRET acceptors should further expand the multiplexing capability of BRET and improve its applicability and sensitivity for in vivo imaging applications.

Indexed as

Energy TransferBiosensing TechniquesFluorescence Resonance Energy TransferLuminescent MeasurementsLuminescent ProteinsModels, TheoreticalNanotechnologyQuantum DotsLuminescent Proteins

Identifiers

PMID19216068
PMCPMC2680468
OpenAlexW2107547475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.