ArticleBiomaterials2009
Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections.
Article in Biomaterials, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants─Systematic Review and Meta-Analysis.ACS biomaterials science & engineering · 2022Pooled it
- A systematic review of animal models for Staphylococcus aureus osteomyelitis.European cells & materials · 2014Pooled it
- Antimicrobial Peptide Identified via Machine Learning Presents Both Potent Antibacterial Properties and Low Toxicity toward Human Cells.Microorganisms · 2024Article
- The osteoblast secretome inFrontiers in immunology · 2022Review
- Multidrug-Resistant Bacteria: Their Mechanism of Action and Prophylaxis.BioMed research international · 2022Review
- Programmed Multidrug Delivery Based on Bio-Inspired Capsule-Integrated Nanocoatings for Infected Bone Defect Treatment.ACS applied materials & interfaces · 2021Article
- Direct Microscopic Observation of Human Neutrophil-Staphylococcus aureus InteractionInfection and immunity · 2019Article
- [Application of nanodrug carriers in the prevention and treatment of infection around orthopedic prosthesis].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Review
- Strategically prolonged release of multiple antibacterial components from a thin film coating for synergistic effects againstRSC advances · 2019Article
- Recent advances in musculoskeletal local drug delivery.Acta biomaterialia · 2019Review
- Capsule-Integrated Polypeptide Multilayer Films for Effective pH-Responsive Multiple Drug Co-Delivery.ACS applied materials & interfaces · 2018Article
- Biomimetic Layer-by-Layer Self-Assembly of Nanofilms, Nanocoatings, and 3D Scaffolds for Tissue Engineering.International journal of molecular sciences · 2018Review
- Bacteria antibiotic resistance: New challenges and opportunities for implant-associated orthopedic infections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Molecular characterization and antibacterial effect of endophytic actinomycetesBioactive materials · 2016Article
- Dual mode antibacterial activity of ion substituted calcium phosphate nanocarriers for bone infections.Frontiers in bioengineering and biotechnology · 2015Article
- Current Concepts and Ongoing Research in the Prevention and Treatment of Open Fracture Infections.Advances in wound care · 2015Review
- Antibacterial surface treatment for orthopaedic implants.International journal of molecular sciences · 2014Review
- Differential responses of osteoblasts and macrophages upon Staphylococcus aureus infection.BMC microbiology · 2014Article
- Electro-spinning/netting: A strategy for the fabrication of three-dimensional polymer nano-fiber/nets.Progress in materials science · 2013Review
- Unique antimicrobial effects of platelet-rich plasma and its efficacy as a prophylaxis to prevent implant-associated spinal infection.Advanced healthcare materials · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Biomedical device-associated infection is one of the most common and problematic complications faced by millions of patients worldwide. The current antibiotic therapy strategies face challenges, the most serious of which is antibiotic resistance. Studies have shown that the systemic level of interleukin 12 (IL-12) decreases following major injuries resulting in decreased cell-mediated immune response. Here we report the development of IL-12 nanoscale coatings using electrostatic layer-by-layer self-assembly nanotechnology. We found that IL-12 nanoscale coatings at the implant/tissue interface substantially decrease infections in vivo, and IL-12 nanoscale coatings are advantageous over traditional treatments. This approach could be a revolutionary step toward preventing device-associated infections using a non-antibiotic approach.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.