ArticleDental materials : official publication of the Academy of Dental Materials2009
In vitro remineralization of enamel by polymeric amorphous calcium phosphate composite: quantitative microradiographic study.
Article in Dental materials : official publication of the Academy of Dental Materials, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed, 243 citations in OpenAlex.
- Clinical evaluation of the efficacy of one self-adhesive composite in dental hypersensitivity.Clinical oral investigations · 2015Trial
- Novel calcium phosphate nanocomposite with caries-inhibition in a human in situ model.Dental materials : official publication of the Academy of Dental Materials · 2013Trial
- Effect of amorphous calcium phosphate and silver nanocomposites on dental plaque microcosm biofilms.Journal of biomedical materials research. Part B, Applied biomaterials · 2012Trial
- Enamel Remineralizing Agents: State of the Art.Materials (Basel, Switzerland) · 2026Review
- Evaluation of microleakage and remineralization potential of a fissure sealant containing microcapsules on artificial enamel lesions: with and without adhesive application.BMC oral health · 2026Article
- Development of Remineralizing and Antibacterial Resin Coating for Provisional Crowns with Improved Bond Strength and Wear Resistance.Polymers · 2026Article
- Effect of flash-free polymeric adhesive on enamel surface after orthodontic bracket debonding under simulated cariogenic and gastric acid conditions.Frontiers in dental medicine · 2026Article
- Effect of biomimetic tooth mousse and toothpaste on the incidence of white spot lesions during fixed appliance orthodontic treatment: A randomized clinical trial.Journal of Taibah University Medical Sciences · 2025Article
- Acid resistance and bond strength of calcium-containing adhesive on enamel.International dental journal · 2025Article
- Debonding Characteristic and Survival Probability of Adhesive Flash-Free Ceramic Orthodontic Brackets Following pH Cycling.European journal of dentistry · 2025Article
- Evaluation of Mechanical and Elemental Properties of Bioceramic-Coated Orthodontic Brackets and Enamel Surface.European journal of dentistry · 2025Article
- Calcium and Microhardness Quantification in Healthy and Fluorotic Dentin Conditioned with a Self-Etching System: An In Vitro Study.Dentistry journal · 2025Article
- The effect of silver and calcium fluoride nanoparticles on antibacterial activity of composite resin againstDental research journal · 2024Article
- Experimental Composite Resin with Myristyltrimethylammonium Bromide (MYTAB) and Alpha-Tricalcium Phosphate (α-TCP): Antibacterial and Remineralizing Effect.Journal of functional biomaterials · 2023Article
- Bonding durability and remineralizing efficiency of orthodontic adhesive containing titanium tetrafluoride: an invitro study.BMC oral health · 2023Article
- Intrafibrillar mineralization of type I collagen by micelle-loaded amorphous calcium phosphate nanoparticles.RSC advances · 2023Article
- The Effect of a Bioactive Oral System and CODiagnostics (Basel, Switzerland) · 2023Article
- Bioceramic micro-fillers reinforce antibiofilm and remineralization properties of clear aligner attachment materials.Frontiers in bioengineering and biotechnology · 2023Article
- Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites.Pharmaceutics · 2022Article
- Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis study explores the efficacy of an experimental orthodontic amorphous calcium phosphate (ACP) composite to remineralize in vitro subsurface enamel lesions microradiographically similar to those seen in early caries.
methodsLesions were artificially created in extracted human molars. Single tooth sections a minimum of 120microm thick were cut and individually placed in holders exposing only the carious enamel surface. The exposed surfaces were either left untreated (control) or coated with a 1mm thick layer of the experimental ACP composite (mass fraction 40% zirconia-hybridized ACP and 60% photo-activated resin), or a commercial fluoride-releasing orthodontic cement. The composite-coated sections were then photo-cured and microradiographic images were taken of all three groups of specimens before the treatment. Specimens were then cyclically immersed in demineralizing and remineralizing solutions for 1 month at 37 degrees C to simulate the pH changes occurring in the oral environment. Microradiographs of all specimens were taken before and after treatment.
resultsQuantitative digital image analysis of matched areas from the contact microradiographs taken before and after treatment indicated higher mineral recovery with ACP composites compared to the commercial orthodontic F-releasing cement (14.4% vs. 4.3%, respectively), while the control specimens showed an average of 55.4% further demineralization. SIGNIFICANCE: Experimental ACP composite efficiently established mineral ion transfer throughout the body of the lesions and restored the mineral lost due to acid attack. It can be considered a useful adjuvant for the control of caries in orthodontic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.