ArticleVirology2009
Porcine circovirus type 2 replication is impaired by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway.
Article in Virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Isolation and pathogenicity of porcine circovirus type 2 in mice from Guangxi province, China.Virology journal · 2023Article
- Review
- Activation of the extracellular signal-regulated kinase pathway is required for replication of Newcastle disease virus.Archives of virology · 2021Article
- Porcine deltacoronavirus activates the Raf/MEK/ERK pathway to promote its replication.Virus research · 2020Article
- Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells.Pathogens (Basel, Switzerland) · 2020Article
- Porcine Circovirus Type 2 Rep Enhances IL-10 Production in Macrophages via Activation of p38-MAPK Pathway.Viruses · 2019Article
- p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells.Veterinary research · 2016Article
- Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway.Journal of virology · 2016Article
- JNK and p38 mitogen-activated protein kinase pathways contribute to porcine epidemic diarrhea virus infection.Virus research · 2016Article
- Interactions of porcine circovirus 2 with its hosts.Virus genes · 2016Review
- Involvement of miR-15a in G0/G1 Phase Cell Cycle Arrest Induced by Porcine Circovirus Type 2 Replication.Scientific reports · 2016Article
- Article
- Extracellular signal-regulated kinase (ERK) activation is required for porcine epidemic diarrhea virus replication.Virology · 2015Article
- Changes in cellular microRNA expression induced by porcine circovirus type 2-encoded proteins.Veterinary research · 2015Article
- Identification of microRNAs in PCV2 subclinically infected pigs by high throughput sequencing.Veterinary research · 2015Article
- Ochratoxin A promotes porcine circovirus type 2 replication in vitro and in vivo.Free radical biology & medicine · 2015Article
- Porcine circovirus type 2 induces autophagy via the AMPK/ERK/TSC2/mTOR signaling pathway in PK-15 cells.Journal of virology · 2012Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postweaning multisystemic wasting syndrome, which is primarily caused by porcine circovirus type 2 (PCV2), is an emerging and important swine disease. We have recently shown that PCV2 induces nuclear factor kappa B activation and its activation is required for active replication, but the other cellular factors involved in PCV2 replication are not well defined. The extracellular signal-regulated kinase (ERK) which served as an important component of cellular signal transduction pathways has been shown to regulate many viral infections. In this report, we show that PCV2 activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication. The PCV2-induced ERK1/2 leads to phosphorylation of the ternary complex factor Elk-1, which kinetically paralleled ERK1/2 activation. Inhibition of ERK activation with U0126, a specific MEK1/2 inhibitor, significantly reduced viral progeny release. Investigations into the mechanism of ERK1/2 regulation revealed that inhibition of ERK activation leads to decreased viral transcription and lower virus protein expression. These data indicate that the ERK signaling pathway is involved in PCV2 infection and beneficial to PCV2 replication in the cultured cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.