ArticleInternational journal of radiation oncology, biology, physics2009
Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response.
Article in International journal of radiation oncology, biology, physics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Structural and Functional Characteristics of the Liver After Fractionated Local Electron Irradiation and Against the Background of Ascorbic Acid Administration.Journal of personalized medicine · 2026Review
- Post-Weaning Exposure to Sunset Yellow FCF Induces Changes in Testicular Tight and Gap Junctions in Rats: Protective Effects of Coenzyme Q10.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Supplemental Ferulic Acid Inhibits Total Body Irradiation-Mediated Bone Marrow Damage, Bone Mass Loss, Stem Cell Senescence, and Hematopoietic Defect in Mice by Enhancing Antioxidant Defense Systems.Antioxidants (Basel, Switzerland) · 2021Article
- Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation.Radiation research · 2017Article
- Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity.Free radical biology & medicine · 2016Article
- Emerging targets for radioprotection and radiosensitization in radiotherapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- SOD2 Mediates Amifostine-Induced Protection against Glutamate in PC12 Cells.Oxidative medicine and cellular longevity · 2016Article
- Comments on the mechanisms of action of radiation protective agents: basis components and their polyvalence.SpringerPlus · 2014Review
- Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender.Radiation research · 2013Article
- A survivin-associated adaptive response in radiation therapy.Cancer research · 2013Article
- A manganese superoxide dismutase (SOD2)-mediated adaptive response.Radiation research · 2013Article
- Radioprotective potential of histamine on rat small intestine and uterus.European journal of histochemistry : EJH · 2012Article
- Radiation-induced chronic oxidative renal damage can be reduced by amifostine.Medical oncology (Northwood, London, England) · 2012Article
- Toll-like receptor 5 agonist protects mice from dermatitis and oral mucositis caused by local radiation: implications for head-and-neck cancer radiotherapy.International journal of radiation oncology, biology, physics · 2012Article
- Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury.Critical care medicine · 2011Article
- SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine.Free radical biology & medicine · 2011Article
- Salen Mn complexes mitigate radiation injury in normal tissues.Anti-cancer agents in medicinal chemistry · 2011Review
- Modifying radiation damage.Current drug targets · 2010Review
- Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity.Radiation research · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo determine whether amifostine can induce elevated manganese superoxide dismutase (SOD2) in murine tissues and a transplantable SA-NH tumor, resulting in a delayed tumor cell radioprotective effect. METHODS AND MATERIALS: SA-NH tumor-bearing C3H mice were treated with a single 400 mg/kg or three daily 50 mg/kg doses of amifostine administered intraperitoneally. At selected time intervals after the last injection, the heart, liver, lung, pancreas, small intestine, spleen, and SA-NH tumor were removed and analyzed for SOD2, catalase, and glutathione peroxidase (GPx) enzymatic activity. The effect of elevated SOD2 enzymatic activity on the radiation response of SA-NH cells was determined.
resultsSOD2 activity was significantly elevated in selected tissues and a tumor 24 h after amifostine treatment. Catalase and GPx activities remained unchanged except for significant elevations in the spleen. GPx was also elevated in the pancreas. SA-NH tumor cells exhibited a twofold elevation in SOD2 activity and a 27% elevation in radiation resistance. Amifostine administered in three daily fractions of 50 mg/kg each also resulted in significant elevations of these antioxidant enzymes.
conclusionsAmifostine can induce a delayed radioprotective effect that correlates with elevated levels of SOD2 activity in SA-NH tumor. If limited to normal tissues, this delayed radioprotective effect offers an additional potential for overall radiation protection. However, amifostine-induced elevation of SOD2 activity in tumors could have an unanticipated deleterious effect on tumor responses to fractionated radiation therapy, given that the radioprotector is administered daily just before each 2-Gy fractionated dose.
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Registered trials
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