ReviewJournal of anatomy2009
Blastocyst environment and its influence on offspring cardiovascular health: the heart of the matter.
Review in Journal of anatomy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04628091 (Characterization of Persistent Organic Pollutants Exposure During Preconception and Preimplantation Development in the Human Fallopian Tube), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterization of Persistent Organic Pollutants Exposure During Preconception and Preimplantation Development in the Human Fallopian Tube: TUBPOP.
Who cites it
15 citing papers in PubMed.
- Effect of a micronutrient-rich snack taken preconceptionally and throughout pregnancy on ultrasound measures of fetal growth: The Mumbai Maternal Nutrition Project (MMNP).Maternal & child nutrition · 2018Trial
- Chloroquine mitigates long-term effects of in vitro culture in mouse embryos.Frontiers in cell and developmental biology · 2025Article
- Sex-specific effects ofJournal of molecular and cellular cardiology plus · 2023Article
- Assessing the influence of distinct culture media on human pre-implantation development using single-embryo transcriptomics.Frontiers in cell and developmental biology · 2023Article
- Risk of Higher Blood Pressure in 3 to 6 Years Old Singleton Born From OHSS Patients Undergone With Fresh IVF/ICSI.Frontiers in endocrinology · 2022Article
- Vascular Health of Children Conceived via In Vitro Fertilization.The Journal of pediatrics · 2019Article
- Metabolic Syndrome and Its Components in Young Adults Conceived by ICSI.International journal of endocrinology · 2018Article
- Review
- Early onset intrauterine growth restriction in a mouse model of gestational hypercholesterolemia and atherosclerosis.BioMed research international · 2014Article
- Fetal programming and the risk of noncommunicable disease.Indian journal of pediatrics · 2013Review
- Cardiometabolic health of children conceived by assisted reproductive technologies.Fertility and sterility · 2013Review
- The clinical need for a method of identification of embryos destined to become a blastocyst in assisted reproductive technology cycles.Journal of assisted reproduction and genetics · 2012Article
- Are there subtle genome-wide epigenetic alterations in normal offspring conceived by assisted reproductive technologies?Fertility and sterility · 2011Review
- Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring.BMC biology · 2011Article
- Nutritional effects on oocyte and embryo development in mammals: implications for reproductive efficiency and environmental sustainability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The development of adult-onset diseases such as type II diabetes, obesity and cardiovascular disease is traditionally attributed to adult lifestyle characteristics such as a lack of physical exercise, poor diet and smoking. However, evidence from both human and animal model studies has demonstrated that environmental factors such as an imbalance or reduction in maternal nutrition during gestation can have adverse effects on offspring metabolism and cardiovascular health. The severity and nature of the phenotypic changes induced in offspring is influenced by the period of gestation manipulated. In particular, the mammalian preimplantation embryo in different animal models displays particular sensitivity to environmental factors, either in vivo (maternal diet) or in vitro (embryo culture) that is associated with the onset of cardiovascular dysfunction in adult life. The detailed mechanisms by which environmental conditions can alter postnatal cardiovascular physiology are poorly understood. However, various factors including endothelial function, vascular responsiveness, the renin-angiotensin system, kidney structure and early postnatal growth dynamics have all been recognize as potential contributors. Here, we review the relationship between preimplantation embryo environment and postnatal cardiovascular disease risk, and consider biochemical, molecular, genetic and physiological pathways implicated in this association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.