ReviewEndocrine pathology2009
Keratin expression in endocrine organs and their neoplasms.
Review in Endocrine pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Keratin 20 Suppresses Exosomal Secretion of Peroxiredoxin 2 and Ferroptosis in Acute Kidney Injury.Journal of the American Society of Nephrology : JASN · 2026Article
- Investigating monoclonal antibody against cytokeratin 19 tumor marker.BMC immunology · 2025Article
- Histological Characteristics of Non-alcoholic Steatohepatitis in NAFLD Patients With Low Degree of Hepatocyte Apoptosis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- An Algorithmic Immunohistochemical Approach to Define Tumor Type and Assign Site of Origin.Advances in anatomic pathology · 2020Review
- High expression of cytokeratin CAM5.2 in esophageal squamous cell carcinoma is associated with poor prognosis.Medicine · 2019Article
- Examination of PHOX2B in adult neuroendocrine neoplasms reveals relatively frequent expression in phaeochromocytomas and paragangliomas.Histopathology · 2017Article
- A Strong Neutrophil Elastase Proteolytic Fingerprint Marks the Carcinoma Tumor Proteome.Molecular & cellular proteomics : MCP · 2017Article
- Metastatic papillary thyroid carcinoma to the nose: report and review of cutaneous metastases of papillary thyroid cancer.Dermatology practical & conceptual · 2015Article
- Overexpression of cytokeratin 17 is associated with the development of papillary thyroid carcinoma and the presence of lymph node metastasis.International journal of clinical and experimental pathology · 2015Article
- Article
- Short histological kaleidoscope - recent findings in histology. Part IV.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
- Presence of Cytokeratin 19-Expressing Cholangiocarcinoma-Like Tumour in a Liver Metastatic Lesion of Rectal Neuroendocrine Tumour.Case reports in gastroenterologyArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratins are intermediate filaments that provide mechanical support and fulfill a variety of additional functions in epithelial cells. Keratins show outstanding degree of molecular diversity. In humans, 54 functional keratin genes exist. Twenty common types of keratins are expressed in highly specific patterns related to epithelial type and stage of cellular differentiation. In general, keratins are classified as high-molecular-weight keratins (expressed in normal stratified epithelium and tumors derived from it) and low-molecular-weight keratins (expressed in normal simple epithelium and tumors derived from it). Histologically, endocrine organs belong to simple epithelium; thus, endocrine tissues usually express low-molecular-weight keratins. When an endocrine organ undergoes malignant transformation, its keratin profile usually remains constant. However, keratin expression in endocrine organs and endocrine tumors is much more complicated because of their diversified histogenesis. In this review article, we will first briefly review the molecular biology and protein chemistry of the keratins. We will then review the expression patterns of keratins in normal endocrine tissue and endocrine neoplasms.
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