ArticlePurinergic signalling2009
The P2X(7) receptor and intracellular pathogens: a continuing struggle.
Article in Purinergic signalling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine.The Journal of biological chemistry · 2013Trial
- Persistent Activation of the P2X7 Receptor Underlies Chronic Inflammation and Carcinogenic Changes in the Intestine.International journal of molecular sciences · 2024Review
- The P2XFrontiers in cellular neuroscience · 2021Article
- Article
- Neuroprotective role of resveratrol mediated by purinergic signalling in cerebral cortex of mice infected by Toxoplasma gondii.Parasitology research · 2020Article
- Immunological Pathways Triggered byMediators of inflammation · 2019Review
- Review
- The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control.Purinergic signalling · 2017Article
- Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response.Biomedical journal · 2016Review
- Purinergic signaling during Porphyromonas gingivalis infection.Biomedical journal · 2016Review
- Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.Nature communications · 2016Article
- The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity.Periodontology 2000 · 2015Review
- Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophages.Pflugers Archiv : European journal of physiology · 2015Article
- Extracellular adenosine generation in the regulation of pro-inflammatory responses and pathogen colonization.Biomolecules · 2015Review
- Article
- Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages.PloS one · 2015Article
- Purinergic signalling and immune cells.Purinergic signalling · 2014Review
- Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses.Purinergic signalling · 2013Review
- Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor/NADPH-oxidase signalling and contributes to persistence.Cellular microbiology · 2013Article
- Endothelial P2X7 receptors' expression is reduced by schistosomiasis.Purinergic signalling · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purinergic receptor, P2X(7), has recently emerged as an important component of the innate immune response against microbial infections. Ligation of P2X(7) by ATP can stimulate inflammasome activation and secretion of proinflammatory cytokines, but it can also lead directly to killing of intracellular pathogens in infected macrophages and epithelial cells. Thus, while some intracellular pathogens evade host defense responses by modulating with membrane trafficking or cell signaling in the infected cells, the host cells have also developed mechanisms for inhibiting infection. This review will focus on the effects of P2X(7) on control of infection by intracellular pathogens, microbial virulence factors that interfere with P2X(7) activity, and recent evidence linking polymorphisms in human P2X(7) with susceptibility to infection.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.