ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2009
Specific patterns of histone marks accompany X chromosome inactivation in a marsupial.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Koala methylomes reveal divergent and conserved DNA methylation signatures of X chromosome regulation.Proceedings. Biological sciences · 2021Article
- The methylation and telomere landscape in two families of marsupials with different rates of chromosome evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018Article
- Meiotic behavior and H3K4m distribution in B chromosomes of Characidium gomesi (Characiformes, Crenuchidae).Comparative cytogenetics · 2016Article
- Evolution of vertebrate sex chromosomes and dosage compensation.Nature reviews. Genetics · 2016Review
- Weird mammals provide insights into the evolution of mammalian sex chromosomes and dosage compensation.Journal of genetics · 2015Review
- Intrinsically disordered proteins in the nucleus of human cells.Biochemistry and biophysics reports · 2015Article
- Immunofluorescent staining reveals hypermethylation of microchromosomes in the central bearded dragon, Pogona vitticeps.Molecular cytogenetics · 2015Article
- Disordered proteinaceous machines.Chemical reviews · 2014Review
- Genome-wide histone state profiling of fibroblasts from the opossum, Monodelphis domestica, identifies the first marsupial-specific imprinted gene.BMC genomics · 2014Article
- Chromosome-wide profiling of X-chromosome inactivation and epigenetic states in fetal brain and placenta of the opossum, Monodelphis domestica.Genome research · 2014Article
- Chromosome-wide regulation of euchromatin-specific 5mC to 5hmC conversion in mouse ES cells and female human somatic cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Review
- Article
- Finding a balance: how diverse dosage compensation strategies modify histone h4 to regulate transcription.Genetics research international · 2012Article
- Peromyscus as a Mammalian epigenetic model.Genetics research international · 2012Article
- Review
- HIstome--a relational knowledgebase of human histone proteins and histone modifying enzymes.Nucleic acids research · 2012Article
- Evolutionary diversity and developmental regulation of X-chromosome inactivation.Human genetics · 2011Review
- Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation.Nature reviews. Genetics · 2011Review
- The demoiselle of X-inactivation: 50 years old and as trendy and mesmerising as ever.PLoS genetics · 2011Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inactivation of one of the two X chromosomes in female placental mammals represents a remarkable example of epigenetic silencing. X inactivation occurs also in marsupial mammals, but is phenotypically different, being incomplete, tissue-specific and paternal. Paternal X inactivation occurs also in the extraembryonic cells of rodents, suggesting that imprinted X inactivation represents a simpler ancestral mechanism. This evolved into a complex and random process in placental mammals under the control of the XIST gene, involving notably variant and modified histones. Molecular mechanisms of X inactivation in marsupials are poorly known, but occur in the absence of an XIST homologue. We analysed the specific pattern of histone modifications using immunofluorescence on metaphasic chromosomes of a model kangaroo, the tammar wallaby. We found that all active marks are excluded from the inactive X in marsupials, as in placental mammals, so this represents a common feature of X inactivation throughout mammals. However, we were unable to demonstrate the accumulation of inactive histone marks, suggesting some fundamental differences in the molecular mechanism of X inactivation between marsupial and placental mammals. A better understanding of the epigenetic mechanisms underlying X inactivation in marsupials will provide important insights into the evolution of this complex process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.