ArticlePLoS computational biology2009
Stochastically gating ion channels enable patterned spike firing through activity-dependent modulation of spike probability.
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Heterogeneous stochastic bifurcations explain intrinsic oscillatory patterns in entorhinal cortical stellate cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dendritic spine morphology regulates calcium-dependent synaptic weight change.The Journal of general physiology · 2022Article
- Degeneracy in the robust expression of spectral selectivity, subthreshold oscillations, and intrinsic excitability of entorhinal stellate cells.Journal of neurophysiology · 2018Article
- Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells.Journal of theoretical biology · 2018Article
- Physiological Properties of Neurons in Bat Entorhinal Cortex Exhibit an Inverse Gradient along the Dorsal-Ventral Axis Compared to Entorhinal Neurons in Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Activation of Ih and TTX-sensitive sodium current at subthreshold voltages during CA1 pyramidal neuron firing.Journal of neurophysiology · 2015Article
- How to build a grid cell.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise.Frontiers in computational neuroscience · 2014Article
- Article
- HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus.Neuroscience · 2013Article
- Somatic versus dendritic resonance: differential filtering of inputs through non-uniform distributions of active conductances.PloS one · 2013Article
- Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells.Journal of neurophysiology · 2013Article
- Firing rate and pattern heterogeneity in the globus pallidus arise from a single neuronal population.Journal of neurophysiology · 2013Article
- The limits of brain determinacy.Proceedings. Biological sciences · 2012Review
- Intrinsic electrophysiological properties of entorhinal cortex stellate cells and their contribution to grid cell firing fields.Frontiers in neural circuits · 2012Article
- Dorsal-ventral organization of theta-like activity intrinsic to entorhinal stellate neurons is mediated by differences in stochastic current fluctuations.The Journal of physiology · 2011Article
- Population diversity and function of hyperpolarization-activated current in olfactory bulb mitral cells.Scientific reports · 2011Article
- Article
- Stochastic ion channel gating in dendritic neurons: morphology dependence and probabilistic synaptic activation of dendritic spikes.PLoS computational biology · 2010Article
- Cholinergic modulation of the resonance properties of stellate cells in layer II of medial entorhinal cortex.Journal of neurophysiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The transformation of synaptic input into patterns of spike output is a fundamental operation that is determined by the particular complement of ion channels that a neuron expresses. Although it is well established that individual ion channel proteins make stochastic transitions between conducting and non-conducting states, most models of synaptic integration are deterministic, and relatively little is known about the functional consequences of interactions between stochastically gating ion channels. Here, we show that a model of stellate neurons from layer II of the medial entorhinal cortex implemented with either stochastic or deterministically gating ion channels can reproduce the resting membrane properties of stellate neurons, but only the stochastic version of the model can fully account for perithreshold membrane potential fluctuations and clustered patterns of spike output that are recorded from stellate neurons during depolarized states. We demonstrate that the stochastic model implements an example of a general mechanism for patterning of neuronal output through activity-dependent changes in the probability of spike firing. Unlike deterministic mechanisms that generate spike patterns through slow changes in the state of model parameters, this general stochastic mechanism does not require retention of information beyond the duration of a single spike and its associated afterhyperpolarization. Instead, clustered patterns of spikes emerge in the stochastic model of stellate neurons as a result of a transient increase in firing probability driven by activation of HCN channels during recovery from the spike afterhyperpolarization. Using this model, we infer conditions in which stochastic ion channel gating may influence firing patterns in vivo and predict consequences of modifications of HCN channel function for in vivo firing patterns.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.