ArticleJournal of acquired immune deficiency syndromes (1999)2009
Nonstructured treatment interruptions among injection drug users in Baltimore, MD.
Article in Journal of acquired immune deficiency syndromes (1999), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Barriers and facilitators to primary care engagement for people who inject drugs: A systematic review.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2023Pooled it
- Systematic review of HIV treatment adherence research among people who inject drugs in the United States and Canada: evidence to inform pre-exposure prophylaxis (PrEP) adherence interventions.BMC public health · 2019Pooled it
- HIV treatment outcomes among HIV-infected, opioid-dependent patients receiving buprenorphine/naloxone treatment within HIV clinical care settings: results from a multisite study.Journal of acquired immune deficiency syndromes (1999) · 2011Trial
- Clinic-based treatment of opioid-dependent HIV-infected patients versus referral to an opioid treatment program: A randomized trial.Annals of internal medicine · 2010Trial
- Mortality among people who inject drugs: a prospective cohort followed over three decades in Baltimore, MD, USA.Addiction (Abingdon, England) · 2022Article
- Nonstructured Treatment Interruptions Are Associated With Higher Human Immunodeficiency Virus Reservoir Size Measured by Intact Proviral DNA Assay in People Who Inject Drugs.The Journal of infectious diseases · 2021Article
- Stopping, starting, and sustaining HIV antiretroviral therapy: a mixed-methods exploration among African American/Black and Latino long-term survivors of HIV in an urban context.BMC public health · 2021Article
- HIV Drug Resistance Mutations Detection by Next-Generation Sequencing during Antiretroviral Therapy Interruption in China.Pathogens (Basel, Switzerland) · 2021Article
- Risk factors for antiretroviral therapy (ART) discontinuation in a large multinational trial of early ART initiators.AIDS (London, England) · 2019Article
- Observational
- Antiretroviral Therapy Use Among HIV-Infected People Who Inject Drugs-20 Cities, United States, 2009-2015.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Effects of unplanned treatment interruptions on HIV treatment failure - results from TAHOD.Tropical medicine & international health : TM & IH · 2016Observational
- Environmental Factors Related to Pulmonary Tuberculosis in HIV-Infected Patients in the Combined Antiretroviral Therapy (cART) Era.PloS one · 2016Article
- Risk factors for unstructured treatment interruptions and association with survival in low to middle income countries.AIDS research and therapy · 2016Article
- Frailty, Inflammation, and Mortality Among Persons Aging With HIV Infection and Injection Drug Use.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Characterizing retention in HAART as a recurrent event process: insights into 'cascade churn'.AIDS (London, England) · 2015Article
- Uptake and Acceptability of Information and Communication Technology in a Community-Based Cohort of People Who Inject Drugs: Implications for Mobile Health Interventions.JMIR mHealth and uHealth · 2015Article
- Level of adherence and HIV RNA suppression in the current era of highly active antiretroviral therapy (HAART).AIDS and behavior · 2015Article
- Response to: The relationship of physical performance with HIV disease and mortality: a cohort study.AIDS (London, England) · 2015Article
- Predictors of unstructured antiretroviral treatment interruption and resumption among HIV-positive individuals in Canada.HIV medicine · 2015Observational
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundWe characterized patterns of highly active antiretroviral therapy (HAART) use and predictors of nonstructured treatment interruptions (NTIs) among injection drug users (IDUs) in Baltimore, MD.
methodsThree hundred thirty-five IDUs who initiated HAART from 1996 to 2006 were studied. NTIs were defined as any subsequent 6-month interval where HAART was not reported. Predictors of the first NTI and subsequent restart of HAART were examined using Cox regression.
resultsTwo hundred sixty (78%) reported > or =1 NTI. Of 215 with > or =1 follow-up visit after the NTI, 44 (20%) never restarted HAART, 62 (29%) restarted and remained on HAART, and 109 (51%) reported multiple NTIs. NTIs were less likely among those who initiated HAART in later calendar years and had a recent outpatient visit and more likely among women, persons with detectable HIV RNA at the prior visit, and those who reported injecting daily. Among those with NTIs, interuptions occurred earlier in persons who were younger, who did not have a prior AIDS diagnosis, and who were actively injecting; NTIs lasted longer in persons who had higher HIV RNA levels, in persons who were incarcerated, and in persons drinking alcohol. A recent outpatient visit and not actively injecting were associated with restarting HAART.
conclusionsNTIs were common in this population and occurred most frequently in the setting of active drug use and disruption of health care. Effective linkages between primary care for HIV and substance abuse treatment may improve HAART outcomes in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.