ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
Genesis of gasping is independent of levels of serotonin in the Pet-1 knockout mouse.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice.Journal of molecular cell biology · 2021Article
- Perinatal Hypoxemia and Oxygen Sensing.Comprehensive Physiology · 2021Article
- Secondhand Smoking and Sudden Infant Death Syndrome: How canFrontiers in bioengineering and biotechnology · 2021Article
- Take a deep breath and wake up: The protean role of serotonin preventing sudden death in infancy.Experimental neurology · 2020Review
- The serotonergic system and the control of breathing during development.Respiratory physiology & neurobiology · 2019Review
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
- Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The physiological determinants of sudden infant death syndrome.Respiratory physiology & neurobiology · 2013Review
- Resuscitation and auto resuscitation by airway reflexes in animals.Cough (London, England) · 2013Article
- Molecular genetics of mouse serotonin neurons across the lifespan.Neuroscience · 2011Review
- Postnatal loss of brainstem serotonin neurones compromises the ability of neonatal rats to survive episodic severe hypoxia.The Journal of physiology · 2011Article
- Failed heart rate recovery at a critical age in 5-HT-deficient mice exposed to episodic anoxia: implications for SIDS.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro.The European journal of neuroscience · 2011Article
- The role of medullary serotonin (5-HT) neurons in respiratory control: contributions to eupneic ventilation, CO2 chemoreception, and thermoregulation.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
- Discharge of the hypoglossal nerve cannot distinguish eupnea from gasping, as defined by phrenic discharge, in the in situ mouse.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Eupnea is normal breathing. If eupnea fails, as in severe hypoxia or ischemia, gasping is recruited. Gasping can serve as a powerful mechanism for autoresuscitation. A failure of autoresuscitation has been proposed as a basis of the sudden infant death syndrome. In an in vitro preparation, endogenous serotonin is reported to be essential for expression of gasping. Using an in situ preparation of the Pet-1 knockout mouse, we evaluated such a critical role for serotonin. In this mouse, the number of serotonergic neurons is reduced by 85-90% compared with animals without this homozygous genetic defect. Despite this reduction in the number of serotonergic neurons, phrenic discharge in eupnea and gasping of Pet-1 knockout mice was not different from that of wild-type mice. Indeed, gasping continued unabated, even after administration of methysergide, a blocker of many types of receptors for serotonin, to Pet-1 knockout mice. We conclude that serotonin is not critical for expression of gasping. The proposal for such a critical role, on the basis of observations in the in vitro slice preparation, may reflect the minimal functional neuronal tissue and neurotransmitters in this preparation, such that the role of any remaining neurotransmitters is magnified. Also, rhythmic activity of the in vitro slice preparation has been characterized as eupnea or gasping solely on the basis of activity of the hypoglossal nerve or massed neuronal activities of the ventrolateral medulla. The accuracy of this method of classification has not been established.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.