ArticleEvidence-based complementary and alternative medicine : eCAM2011
Brazilian Green Propolis: Effects In Vitro and In Vivo on Trypanosoma cruzi.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Evaluation of the trypanocidal and immunomodulatory effects of LDT409, a cardanol derivative from cashew nut shell liquid.Frontiers in immunology · 2026Article
- Therapeutic Potential of Propolis in Preclinical Models of Cancer and Infectious Diseases: A Review.International journal of molecular sciences · 2025Review
- Propolis Stands out as a Multifaceted Natural Product: Meta-Analysis on Its Sources, Bioactivities, Applications, and Future Perspectives.Life (Basel, Switzerland) · 2025Review
- Phytochemical profiling and characterization of flavonoid derivatives from propolis sample and investigation of cytotoxic and antiprotozoal activities.Scientific reports · 2024Article
- Evaluation of the antitrypanosomal activity, cytotoxicity and phytochemistry of red Brazilian propolis.PloS one · 2024Article
- Meroterpenoids fromPharmaceuticals (Basel, Switzerland) · 2023Article
- Experimental Combination Therapy with Amiodarone and Low-Dose Benznidazole in a Mouse Model of Trypanosoma cruzi Acute Infection.Microbiology spectrum · 2022Article
- Review
- Review
- The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets.Molecules (Basel, Switzerland) · 2020Review
- Comprehensive multivariate correlations between climatic effect, metabolite-profile, antioxidant capacity and antibacterial activity of Brazilian red propolis metabolites during seasonal study.Scientific reports · 2019Article
- Composition and functional properties of propolis (bee glue): A review.Saudi journal of biological sciences · 2019Review
- Biomarkers as predictive tools to test theBioscience reports · 2018Article
- Antifilarial activity of caffeic acid phenethyl ester on Brugia pahangi in vitro and in vivo.Pathogens and global health · 2017Article
- Antioxidant, antimicrobial, antiparasitic, and cytotoxic properties of various Brazilian propolis extracts.PloS one · 2017Article
- Chemical and Antimicrobial Profiling of Propolis from Different Regions within Libya.PloS one · 2016Article
- Decoding the anti-Trypanosoma cruzi action of HIV peptidase inhibitors using epimastigotes as a model.PloS one · 2014Article
- Optimization on preparation condition of propolis flavonoids liposome by response surface methodology and research of its immunoenhancement activity.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Propolis: a wonder bees product and its pharmacological potentials.Advances in pharmacological sciences · 2013Review
- Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The composition of a Brazilian green propolis ethanolic extract (Et-Bra) and its effect on Trypanosoma cruzi trypomastigotes and other pathogenic microorganisms have already been reported. Here, we further investigated Et-Bra targets in T. cruzi and its effect on experimental infection of mice. The IC(50)/4 days for inhibition of amastigote proliferation was 8.5 ± 1.8 μg mL(-1), with no damage to the host cells. In epimastigotes Et-Bra induced alterations in reservosomes, Golgi complex and mitochondrion. These effects were confirmed by flow cytometry analysis. In trypomastigotes, Et-Bra led to the loss of plasma membrane integrity. The in vitro studies indicate that Et-Bra interferes in the functionality of the plasma membrane in trypomastigotes and of reservosomes and mitochondrion in epimastigotes. Acutely infected mice were treated orally with Et-Bra and the parasitemia, mortality and GPT, GOT, CK and urea levels were monitored. The extract (25-300 mg kg(-1) body weight/day for 10 days) reduced the parasitemia, although not at significant levels; increased the survival of the animals and did not induce any hepatic, muscular lesion or renal toxicity. Since Et-Bra was not toxic to the animals, it could be assayed in combination with other drugs. Et-Bra could be a potential metacyclogenesis blocker, considering its effect on reservosomes, which are an important energy source during parasite differentiation.
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Registered trials
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