ArticleNucleic acids research2009
Darwinian evolution in the light of genomics.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
89 citing papers in PubMed, 253 citations in OpenAlex.
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- The Multi-Causal Basis of Developmental Potential Construction.Acta biotheoretica · 2023Article
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- Non-Random Genome Editing and Natural Cellular Engineering in Cognition-Based Evolution.Cells · 2021Review
- The nuclear export protein XPO1 - from biology to targeted therapy.Nature reviews. Clinical oncology · 2021Review
- Analysis of SARS-CoV-2 Variants From 24,181 Patients Exemplifies the Role of Globalization and Zoonosis in Pandemics.Frontiers in microbiology · 2021Article
- Femtoplankton: What's New?Viruses · 2020Review
- Should Networks Supplant Tree Building?Microorganisms · 2020Review
- Experimental manipulation of selfish genetic elements links genes to microbial community function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Importance of adipocyte browning in the evolution of endothermy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Horizontal Gene Transfer and Endophytes: An Implication for the Acquisition of Novel Traits.Plants (Basel, Switzerland) · 2020Review
- Overcoming randomness does not rule out the importance of inherent randomness for functionality.Journal of biosciences · 2019Review
- How microbes "jeopardize" the modern synthesis.PLoS genetics · 2019Article
- Computational biologists: moving to the driver's seat.Genome biology · 2017Article
- Why an extended evolutionary synthesis is necessary.Interface focus · 2017Review
- Neurogenomics and the role of a large mutational target on rapid behavioral change.Biology direct · 2016Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Comparative genomics and systems biology offer unprecedented opportunities for testing central tenets of evolutionary biology formulated by Darwin in the Origin of Species in 1859 and expanded in the Modern Synthesis 100 years later. Evolutionary-genomic studies show that natural selection is only one of the forces that shape genome evolution and is not quantitatively dominant, whereas non-adaptive processes are much more prominent than previously suspected. Major contributions of horizontal gene transfer and diverse selfish genetic elements to genome evolution undermine the Tree of Life concept. An adequate depiction of evolution requires the more complex concept of a network or 'forest' of life. There is no consistent tendency of evolution towards increased genomic complexity, and when complexity increases, this appears to be a non-adaptive consequence of evolution under weak purifying selection rather than an adaptation. Several universals of genome evolution were discovered including the invariant distributions of evolutionary rates among orthologous genes from diverse genomes and of paralogous gene family sizes, and the negative correlation between gene expression level and sequence evolution rate. Simple, non-adaptive models of evolution explain some of these universals, suggesting that a new synthesis of evolutionary biology might become feasible in a not so remote future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.