ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Assessment of myocardial triglyceride oxidation with PET and 11C-palmitate.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Subcutaneous adipose tissue free fatty acid uptake measured using positron emission tomography and adipose biopsies in humans.American journal of physiology. Endocrinology and metabolism · 2019Trial
- Free fatty acid flux measured using [1-American journal of physiology. Endocrinology and metabolism · 2018Trial
- Hybrid imaging of neuroendocrine tumors in the heart: Union is strength.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Narrative review of metabolomics in cardiovascular disease.Journal of thoracic disease · 2021Review
- Positron emission tomography/MRI for cardiac diseases assessment.The British journal of radiology · 2020Review
- Molecular Imaging of the Heart.Comprehensive Physiology · 2019Review
- Radiopharmaceutical tracers for cardiac imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Searching for novel PET radiotracers: imaging cardiac perfusion, metabolism and inflammation.American journal of nuclear medicine and molecular imaging · 2018Review
- SPECT and PET in ischemic heart failure.Heart failure reviews · 2017Review
- Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.Circulation research · 2016Review
- Recent advances in metabolic imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- Equivalence of arterial and venous blood for [11C]CO2-metabolite analysis following intravenous administration of 1-[11C]acetate and 1-[11C]palmitate.Nuclear medicine and biology · 2013Article
- Fatty acid imaging of the heart.Current cardiology reports · 2011Review
- Hyperinsulinemia improves ischemic LV function in insulin resistant subjects.Cardiovascular diabetology · 2010Article
- Radionuclide imaging of myocardial metabolism.Circulation. Cardiovascular imaging · 2010Review
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe goal of this study was to test whether myocardial triglyceride (TG) turnover including oxidation of TG-derived fatty acids (FA) could be assessed with PET and (11)C-palmitate. METHODS AND
resultsA total of 26 dogs were studied fasted (FAST), during Intralipid infusion (IL), during a hyperinsulinemic-euglycemic clamp without (HIEG), or with Intralipid infusion (HIEG + IL). (11)C-palmitate was injected, and 45 minutes were allowed for labeling of myocardial TG pool. 3D PET data were then acquired for 60 minutes, with first 15 minutes at baseline followed by 45 minutes during cardiac work stimulated with constant infusion of either phenylephrine (FAST, n = 6; IL, n = 6; HIEG + IL, n = 6) or dobutamine (FAST, n = 4; HIEG, n = 4). Myocardial (11)C washout during adrenergic stimulation (AS) was fitted to a mono-exponential function (Km(PET)). To determine the source of this (11)C clearance, Km(PET) was compared to direct coronary sinus-arterial measurements of total (11)C activity, (11)C-palmitate, and (11)CO(2). Before AS, PET curves in all groups were flat indicating absence of net clearance of (11)C activity from heart. In both FAST groups, AS resulted in negligible net (11)C activity and (11)CO(2) production higher than net (11)C-palmitate uptake. AS with phenylephrine resulted in net myocardial uptake of total (11)C activity and (11)C-palmitate in IL and HIEG + IL, and (11)CO(2) production lower than (11)C-palmitate uptake. In contrast, AS with dobutamine in HIEG resulted in net clearance of all (11)C metabolites (total (11)C activity, (11)C-palmitate and (11)CO(2)) with (11)CO(2) contributing 66% to endogenous FA oxidation. The AS resulted in significant Km(PET) in all the groups, except HIEG + IL. However, positive correlation between Km(PET) and (11)CO(2) was observed only in HIEG (R (2) = 0.83, P = .09).
conclusionsThis is the first study to demonstrate that using PET and pre-labeling of intracardiac TG pool with (11)C-palmitate, noninvasive assessment of myocardial TG use is feasible under metabolic conditions that favor endogenous TG use such as increased metabolic demand (beta-adrenergic stimulation of cardiac work) with limited availability of exogenous substrate (HIEG).
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