ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2009
Classification and controversies in pathology of ependymomas.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 76 citations in OpenAlex.
- Review and update on pediatric ependymoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Article
- Prognostic Factors and Histopathological Features of Pediatric Intracranial Ependymomas: Nationwide Brain Tumor Registry-based Study of Japan.Neurologia medico-chirurgica · 2022Article
- Adult WHO grade II ependymomas: is Ki67 a sex-specific proliferation marker?Journal of surgical case reports · 2021Article
- Review
- Ependymoma, NOS and anaplastic ependymoma incidence and survival in the United States varies widely by patient and clinical characteristics, 2000-2016.Neuro-oncology practice · 2020Article
- Intracranial ependymomas: molecular insights and translation to treatment.Brain pathology (Zurich, Switzerland) · 2020Review
- Central nervous system ependymoma: clinical implications of the new molecular classification, treatment guidelines and controversial issues.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Review
- Outcome predictors in the management of intramedullary classic ependymoma: An integrative survival analysis.Medicine · 2018Observational
- C11orf95-RELA fusions and upregulated NF-KB signalling characterise a subset of aggressive supratentorial ependymomas that express L1CAM and nestin.Journal of neuro-oncology · 2018Article
- Simultaneous cerebrospinal fluid and hematologic metastases in a high-grade ependymoma.Surgical neurology international · 2018Article
- Region Specific Differences of Claudin-5 Expression in Pediatric Intracranial Ependymomas: Potential Prognostic Role in Supratentorial Cases.Pathology oncology research : POR · 2017Article
- Understanding Ependymoma Oncogenesis: an Update on Recent Molecular Advances and Current Perspectives.Molecular neurobiology · 2017Review
- Supratentorial "vascular" variant of ependymoma: a lesser known morphologic variant and a diagnostic pitfall.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Biology and management of ependymomas.Neuro-oncology · 2016Review
- Nucleolin overexpression is associated with an unfavorable outcome for ependymoma: a multifactorial analysis of 176 patients.Journal of neuro-oncology · 2016Article
- Altered MicroRNA Expression Is Associated with Tumor Grade, Molecular Background and Outcome in Childhood Infratentorial Ependymoma.PloS one · 2016Article
- Low-grade ependymoma with late metastasis: autopsy case study and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Review
- Clinical course and progression-free survival of adult intracranial and spinal ependymoma patients.Neuro-oncology · 2015Article
- MRI characteristics of ependymoblastoma: results from 22 centrally reviewed cases.AJNR. American journal of neuroradiology · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBailey and Cushing established ependymoma as a brain tumour entity in the first brain tumour classification (1926). Diagnosis of ependymomas is not subject to controversy as long as other tumours presenting ependymoma-like features have been ruled out. Grading conversely is a source of debate. Description of histological features establishing diagnosis and grading of ependymomas may help to better understand this controversy.
methodsLiterature has been reviewed using PubMed with the following key words: ependymoma, +/- prognosis, +/- biomaker, +/- grading, +/- immunohistochemistry, +/- proliferative index.
resultsGrading controversy arises from elusive WHO features and individual characteristics of ependymomas including tumour location, tumour pattern/variant and variable expression of biomarkers.
conclusionThere is a need for a grading scheme with a proven general ability to dissociate grades, and to predict individual clinical evolution. Only then will stratified and targeted therapeutics for ependymal tumours be possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.