ArticleNeuroreport2009
T-type calcium channels regulate cortical plasticity in-vivo. [corrected].
Article in Neuroreport, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Neurometabolic and structural alterations of medial septum and hippocampal CA1 in a model of post-operative sleep fragmentation in aged mice: a study combining 1H-MRS and DTI.Frontiers in cellular neuroscience · 2023Article
- CaInternational journal of molecular sciences · 2022Review
- Locus Coeruleus Acid-Sensing Ion Channels Modulate Sleep-Wakefulness and State Transition from NREM to REM Sleep in the Rat.Neuroscience bulletin · 2021Article
- Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits.Frontiers in neural circuits · 2021Review
- Training on an Appetitive Trace-Conditioning Task Increases Adult Hippocampal Neurogenesis and the Expression of Arc, Erk and CREB Proteins in the Dorsal Hippocampus.Frontiers in cellular neuroscience · 2020Article
- T-type calcium channels in synaptic plasticity.Channels (Austin, Tex.) · 2017Review
- T-type calcium channel blockers as neuroprotective agents.Pflugers Archiv : European journal of physiology · 2014Review
- T-type channel-mediated neurotransmitter release.Pflugers Archiv : European journal of physiology · 2014Review
- About sleep's role in memory.Physiological reviews · 2013Review
- Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses.Nature neuroscience · 2011Article
- CaMKIV over-expression boosts cortical 4-7 Hz oscillations during learning and 1-4 Hz delta oscillations during sleep.Molecular brain · 2010Article
- Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Article
- Susceptibility to Calcium Dysregulation during Brain Aging.Frontiers in aging neuroscience · 2009Article
Corrections and comments
- Erratum issuedKraus, Richard L [added]
Authors and funding
15 authors.
Funding
Abstract
T-type voltage-dependent calcium channels may play an important role in synaptic plasticity, but lack of specific antagonists has hampered investigation into this possible function. We investigated the role of the T-type channel in a canonical model of in-vivo cortical plasticity triggered by monocular deprivation. We identified a compound (TTA-I1) with subnanomolar potency in standard voltage clamp assays and high selectivity for the T-type channel. When infused intracortically, TTA-I1 reduced cortical plasticity triggered by monocular deprivation while preserving normal visual response properties. These results show that the T-type calcium channel plays a central role in cortical plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.