ReviewNeuro-Signals2009
Heterotrimeric G-proteins interact directly with cytoskeletal components to modify microtubule-dependent cellular processes.
Review in Neuro-Signals, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- The Role and Mechanisms of G protein-coupled receptors in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Subtype-dependent regulation of Gβγ signalling.Cellular signalling · 2021Review
- Regulators of G Protein Signaling in Analgesia and Addiction.Molecular pharmacology · 2020Review
- Disruption of lipid-raft localized GαNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression.Frontiers in pharmacology · 2018Article
- G protein γ subunit 7 induces autophagy and inhibits cell division.Oncotarget · 2016Article
- Tubulin, actin and heterotrimeric G proteins: coordination of signaling and structure.Biochimica et biophysica acta · 2014Review
- Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton.Nature cell biology · 2013Article
- Non-traditional roles of G protein-coupled receptors in basic cell biology.Molecular bioSystems · 2013Review
- Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells.PloS one · 2013Article
- Non-canonical signaling and localizations of heterotrimeric G proteins.Cellular signalling · 2012Review
- A molecular and structural mechanism for G protein-mediated microtubule destabilization.The Journal of biological chemistry · 2011Article
- TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation.Journal of cellular physiology · 2010Article
- Article
- Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.Molecular and cellular biology · 2010Article
- Adenylate cyclase regulates elongation of mammalian primary cilia.Experimental cell research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
A large percentage of current drugs target G-protein-coupled receptors, which couple to well-known signaling pathways involving cAMP or calcium. G-proteins themselves may subserve a second messenger function. Here, we review the role of tubulin and microtubules in directly mediating effects of heterotrimeric G-proteins on neuronal outgrowth, shape and differentiation. G-protein-tubulin interactions appear to be regulated by neurotransmitter activity, and, in turn, regulate the location of Galpha in membrane microdomains (such as lipid rafts) or the cytosol. Tubulin binds with nanomolar affinity to Gsalpha, Gialpha1 and Gqalpha (but not other Galpha subunits) as well as Gbeta(1)gamma(2) subunits. Galpha subunits destabilize microtubules by stimulating tubulin's GTPase, while Gbetagamma subunits promote microtubule stability. The same region on Gsalpha that binds adenylyl cyclase and Gbetagamma also interacts with tubulin, suggesting that cytoskeletal proteins are novel Galpha effectors. Additionally, intracellular Gialpha-GDP, in concert with other GTPase proteins and Gbetagamma, regulates the position of the mitotic spindle in mitosis. Thus, G-protein activation modulates cell growth and differentiation by directly altering microtubule stability. Further studies are needed to fully establish a structural mechanism of this interaction and its role in synaptic plasticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.