ReviewNeuro-Signals2009
Structural determinants involved in the formation and activation of G protein betagamma dimers.
Review in Neuro-Signals, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- TriCLFF: a multi-modal feature fusion framework using contrastive learning for spatial domain identification.Briefings in bioinformatics · 2025Article
- Development and validation of a sensitive LC-MS/MS assay of GT-14, a novel GαJournal of pharmaceutical and biomedical analysis · 2024Article
- Review
- An atypical heterotrimeric Gα and its interactome suggest an extra-large role in overcoming abiotic and biotic stress.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- Article
- Subtype-dependent regulation of Gβγ signalling.Cellular signalling · 2021Review
- G-Protein Subunit GαFrontiers in microbiology · 2020Article
- GPCR regulation of secretion.Pharmacology & therapeutics · 2018Review
- G protein subunit phosphorylation as a regulatory mechanism in heterotrimeric G protein signaling in mammals, yeast, and plants.The Biochemical journal · 2018Review
- Quantitative Multiple-Reaction Monitoring Proteomic Analysis of Gβ and Gγ Subunits in C57Bl6/J Brain Synaptosomes.Biochemistry · 2017Article
- Type B Heterotrimeric G Protein γ-Subunit Regulates Auxin and ABA Signaling in Tomato.Plant physiology · 2016Article
- Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- G-protein βγ subunit dimers modulate kidney repair after ischemia-reperfusion injury in rats.Molecular pharmacology · 2014Article
- Crossroads between light response and nutrient signalling: ENV1 and PhLP1 act as mutual regulatory pair in Trichoderma reesei.BMC genomics · 2014Article
- Ste18p is a positive control element in the mating process of Candida albicans.Eukaryotic cell · 2014Article
- The inhibitory effect of Gβγ and Gβ isoform specificity on ENaC activity.American journal of physiology. Renal physiology · 2013Article
- Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8.The Journal of physiology · 2013Article
- Regulation of Ca(V)2 calcium channels by G protein coupled receptors.Biochimica et biophysica acta · 2013Review
- Diversity of heterotrimeric G-protein γ subunits in plants.BMC research notes · 2012Article
- Probing heterotrimeric G protein activation: applications to biased ligands.Current pharmaceutical design · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Heterotrimeric G proteins, composed of an alpha, beta and gamma subunit, represent one of the most important and dynamic families of signaling proteins. As a testament to the significance of G protein signaling, the hundreds of seven-transmembrane-spanning receptors that interact with G proteins are estimated to occupy 1-2% of the human genome. This broad diversity of receptors is echoed in the number of potential heterotrimer combinations that can arise from the 23 alpha subunit, 7 beta subunit and 12 gamma subunit isoforms that have been identified. The potential for such vast complexity implies that the receptor G protein interface is the site of much regulation. The historical model for the activation of a G protein holds that activated receptor catalyzes the exchange of GDP for GTP on the alpha subunit, inducing a conformational change that substantially lowers the affinity of alpha for betagamma. This decreased affinity enables dissociation of betagamma from alpha and receptor. The free form of betagamma is thought to activate effectors, until the hydrolysis of GTP by G alpha (aided by RGS proteins) allows the subunits to re-associate, effectively deactivating the G protein until another interaction with activated receptor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.