ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2009
Evolution of non-coding regulatory sequences involved in the developmental process: reflection of differential employment of paralogous genes as highlighted by Sox2 and group B1 Sox genes.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Enhancer Arrays Regulating Developmental Genes: Sox2 Enhancers as a Paradigm.Results and problems in cell differentiation · 2024Article
- Wnt signal-dependent antero-posterior specification of early-stage CNS primordia modeled in EpiSC-derived neural stem cells.Frontiers in cell and developmental biology · 2023Article
- Expression and significance of SOX B1 genes in glioblastoma multiforme patients.Journal of cellular and molecular medicine · 2022Article
- Neural Differentiation of Mouse Embryonic Stem Cells-AnFrontiers in genetics · 2021Article
- ERK Activity Dynamics during Zebrafish Embryonic Development.International journal of molecular sciences · 2018Article
- Article
- Epigenetic activation of Sox2 gene in the developing vertebrate neural plate.Molecular biology of the cell · 2016Article
- Transcription, Signaling Receptor Activity, Oxidative Phosphorylation, and Fatty Acid Metabolism Mediate the Presence of Closely Related Species in Distinct Intertidal and Cold-Seep Habitats.Genome biology and evolution · 2015Article
- Wnt/β-catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse embryonic stem cells.Development (Cambridge, England) · 2014Article
- Article
- Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2.PloS one · 2012Article
- Visualization and exploration of conserved regulatory modules using ReXSpecies 2.BMC evolutionary biology · 2011Article
- Learning biomarkers of pluripotent stem cells in mouse.DNA research : an international journal for rapid publication of reports on genes and genomes · 2011Article
- Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells.Nature · 2011Article
- Evolutionarily conserved, growth plate zone-specific regulation of the matrilin-1 promoter: L-Sox5/Sox6 and Nfi factors bound near TATA finely tune activation by Sox9.Molecular and cellular biology · 2011Article
- Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres.Journal of oncology · 2011Article
- Evolution of gene regulation of pluripotency--the case for wiki tracks at genome browsers.Biology direct · 2010Article
- B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo.PLoS genetics · 2010Article
- Role of SoxB1 transcription factors in development.Cellular and molecular life sciences : CMLS · 2009Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In higher vertebrates, the expression of Sox2, a group B1 Sox gene, is the hallmark of neural primordial cell state during the developmental processes from embryo to adult. Sox2 is regulated by the combined action of many enhancers with distinct spatio-temporal specificities. DNA sequences for these enhancers are conserved in a wide range of vertebrate species, corresponding to a majority of highly conserved non-coding sequences surrounding the Sox2 gene, corroborating the notion that the conservation of non-coding sequences mirrors their functional importance. Among the Sox2 enhancers, N-1 and N-2 are activated the earliest in embryogenesis and regulate Sox2 in posterior and anterior neural plates, respectively. These enhancers differ in their evolutionary history: the sequence and activity of enhancer N-2 is conserved in all vertebrate species, while enhancer N-1 is fully conserved only in amniotes. In teleost embryos, Sox19a/b play the major pan-neural role among the group B1 Sox paralogues, while strong Sox2 expression is limited to the anterior neural plate, reflecting the absence of posterior CNS-dedicated enhancers, including N-1. In Xenopus, neurally expressed SoxD is the orthologue of Sox19, but Sox3 appears to dominate other B1 paralogues. In amniotes, however, Sox19 has lost its group B1 Sox function and transforms into group G Sox15 (neofunctionalization), and Sox2 assumes the dominant position by gaining enhancer N-1 and other enhancers for posterior CNS. Thus, the gain and loss of specific enhancer elements during the evolutionary process reflects the change in functional assignment of particular paralogous genes, while overall regulatory functions attributed to the gene family are maintained.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.