ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Slow conductances could underlie intrinsic phase-maintaining properties of isolated lobster (Panulirus interruptus) pyloric neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Robust dynamical invariants in sequential neural activity.Scientific reports · 2019Article
- Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network.eLife · 2019Article
- Modulator-Gated, SUMOylation-Mediated, Activity-Dependent Regulation of Ionic Current Densities Contributes to Short-Term Activity Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Animal-to-Animal Variability in Neuromodulation and Circuit Function.Cold Spring Harbor symposia on quantitative biology · 2014Review
- Article
- Activation of high and low affinity dopamine receptors generates a closed loop that maintains a conductance ratio and its activity correlate.Frontiers in neural circuits · 2013Article
- Tonic nanomolar dopamine enables an activity-dependent phase recovery mechanism that persistently alters the maximal conductance of the hyperpolarization-activated current in a rhythmically active neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Responses of a bursting pacemaker to excitation reveal spatial segregation between bursting and spiking mechanisms.Journal of computational neuroscience · 2011Article
- Sound rhythms are encoded by postinhibitory rebound spiking in the superior paraolivary nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Slow and persistent postinhibitory rebound acts as an intrinsic short-term memory mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A role for compromise: synaptic inhibition and electrical coupling interact to control phasing in the leech heartbeat CpG.Frontiers in behavioral neuroscience · 2010Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The rhythmic pyloric network of the lobster stomatogastric system approximately maintains phase (that is, the burst durations and durations between the bursts of its neurons change proportionally) when network cycle period is altered by current injection into the network pacemaker (Hooper, 1997a,b). When isolated from the network and driven by rhythmic hyperpolarizing current pulses, the delay to firing after each pulse of at least one network neuron type [pyloric (PY)] varies in a phase-maintaining manner when cycle period is varied (Hooper, 1998). These variations require PY neurons to have intrinsic mechanisms that respond to changes in neuron activity on time scales at least as long as 2 s. Slowly activating and deactivating conductances could provide such a mechanism. We tested this possibility by building models containing various slow conductances. This work showed that such conductances could indeed support intrinsic phase maintenance, and we show here results for one such conductance, a slow potassium conductance. These conductances supported phase maintenance because their mean activation level changed, hence altering neuron postinhibition firing delay, when the rhythmic input to the neuron changed. Switching the sign of the dependence of slow-conductance activation and deactivation on membrane potential resulted in neuron delays switching to change in an anti-phase-maintaining manner. These data suggest that slow conductances or similar slow processes such as changes in intracellular Ca(2+) concentration could underlie phase maintenance in pyloric network neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.