ArticleProceedings of the National Academy of Sciences of the United States of America2009
Cytokinins modulate auxin-induced organogenesis in plants via regulation of the auxin efflux.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 252 citations in OpenAlex.
- SlGRF1 mediates gibberellin signaling to control cut-budding in tomato.Journal of integrative plant biology · 2026Article
- In Vitro Propagation of Endemic Kazakh Tulips: Effects of Temperature and Growth Regulators.Plants (Basel, Switzerland) · 2025Article
- Dressed Up to the Nines: The Interplay of Phytohormones Signaling and Redox Metabolism During Plant Response to Drought.Plants (Basel, Switzerland) · 2025Review
- Primary multistep phosphorelay activation comprises both cytokinin and abiotic stress responses: insights from comparative analysis of Brassica type-A response regulators.Journal of experimental botany · 2024Article
- Dissecting the Roles of the Cytokinin Signaling Network: The Case of De Novo Shoot Apical Meristem Formation.Biomolecules · 2024Review
- CRF transcription factors in the trade-off between abiotic stress response and plant developmental processes.Frontiers in genetics · 2024Review
- New Insights into the Enhancement of Adventitious Root Formation Using N,N'-Bis(2,3-methylenedioxyphenyl)urea.Plants (Basel, Switzerland) · 2023Article
- Plants and Small Molecules: An Up-and-Coming Synergy.Plants (Basel, Switzerland) · 2023Review
- Cytokinins - regulators ofFrontiers in plant science · 2023Review
- Histone Acetyltransferase GCN5 Affects Auxin Transport during Root Growth by Modulating Histone Acetylation and Gene Expression of PINs.Plants (Basel, Switzerland) · 2022Article
- Comprehensive Phytohormone Profiling of Kohlrabi during In Vitro Growth and Regeneration: The Interplay with Cytokinin and Sucrose.Life (Basel, Switzerland) · 2022Article
- Auxin-Cytokinin Cross Talk in Somatic Embryogenesis ofPlants (Basel, Switzerland) · 2022Article
- The sucrose transport regulator OsDOF11 mediates cytokinin degradation during rice development.Plant physiology · 2022Article
- The Photoperiod Stress Response inInternational journal of molecular sciences · 2022Article
- Characterization of phytohormone and transcriptome profiles during protocorm-like bodies development of Paphiopedilum.BMC genomics · 2021Article
- Sucrose transporter in rice.Plant signaling & behavior · 2021Review
- Casting the Net-Connecting Auxin Signaling to the Plant Genome.Cold Spring Harbor perspectives in biology · 2021Review
- Auxin Interactions with Other Hormones in Plant Development.Cold Spring Harbor perspectives in biology · 2021Review
- Integrating the Roles for Cytokinin and Auxin in De Novo Shoot Organogenesis: From Hormone Uptake to Signaling Outputs.International journal of molecular sciences · 2021Review
- Cytokinin-Controlled Gradient Distribution of Auxin inInternational journal of molecular sciences · 2021Review
27 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postembryonic de novo organogenesis represents an important competence evolved in plants that allows their physiological and developmental adaptation to changing environmental conditions. The phytohormones auxin and cytokinin (CK) are important regulators of the developmental fate of pluripotent plant cells. However, the molecular nature of their interaction(s) in control of plant organogenesis is largely unknown. Here, we show that CK modulates auxin-induced organogenesis (AIO) via regulation of the efflux-dependent intercellular auxin distribution. We used the hypocotyl explants-based in vitro system to study the mechanism underlying de novo organogenesis. We show that auxin, but not CK, is capable of triggering organogenesis in hypocotyl explants. The AIO is accompanied by endogenous CK production and tissue-specific activation of CK signaling. CK affects differential auxin distribution, and the CK-mediated modulation of organogenesis is simulated by inhibition of polar auxin transport. CK reduces auxin efflux from cultured tobacco cells and regulates expression of auxin efflux carriers from the PIN family in hypocotyl explants. Moreover, endogenous CK levels influence PIN transcription and are necessary to maintain intercellular auxin distribution in planta. Based on these findings, we propose a model in which auxin acts as a trigger of the organogenic processes, whose output is modulated by the endogenously produced CKs. We propose that an important mechanism of this CK action is its effect on auxin distribution via regulation of expression of auxin efflux carriers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.