ArticleProceedings of the National Academy of Sciences of the United States of America2009
Agonizing over agonism: should asthmatics turn their beta-receptors on or off?
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma.PloS one · 2015Article
- Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.Pharmaceuticals (Basel, Switzerland) · 2012Article
- Novel cAMP signalling paradigms: therapeutic implications for airway disease.British journal of pharmacology · 2012Review
- Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness.The Journal of biological chemistry · 2011Article
- Inhibition of protein phosphatase 2A activity by PI3Kγ regulates β-adrenergic receptor function.Molecular cell · 2011Article
- Label-free integrative pharmacology on-target of drugs at the β(2)-adrenergic receptor.Scientific reports · 2011Article
- Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange.Analytical chemistry · 2010Article
- Clinical implications of the intrinsic efficacy of beta-adrenoceptor drugs in asthma: full, partial and inverse agonism.Current opinion in pulmonary medicine · 2010Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.