ArticlePlant physiology2009
Molecular and genetic evidence for the key role of AtCaM3 in heat-shock signal transduction in Arabidopsis.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed, 254 citations in OpenAlex.
- Reproductive thermotolerance: from flower development to seed initiation.The New phytologist · 2026Review
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- The regulatory mechanisms of CAM/CML gene family in governing mycorrhizal fungi in Cremastra appendiculata (Orchidaceae).BMC plant biology · 2025Article
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- Ferroptosis in plant immunity.Plant communications · 2025Review
- New QTLs involved in the control of stigma position in tomato.BMC plant biology · 2025Article
- Genome-Wide Characterization ofInternational journal of molecular sciences · 2025Article
- Facilitating Maize Seed Germination Under Heat Stress via Exogenous Melatonin.International journal of molecular sciences · 2025Article
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- Comprehensively characterize the soybean CAM/CML gene family, as it provides resistance against both the soybean mosaic virus andFrontiers in plant science · 2025Article
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- Functional validation of AaCaM3 response to high temperature stress in Amorphophallus albus.BMC plant biology · 2024Article
- Genome-wide analysis of the peanut CaM/CML gene family reveals that the AhCML69 gene is associated with resistance to Ralstonia solanacearum.BMC genomics · 2024Article
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- Cytoplasmic CaFrontiers in plant science · 2024Article
- Calcium Signaling and the Response to Heat Shock in Crop Plants.International journal of molecular sciences · 2023Review
- Regulatory network of rice in response to heat stress and its potential application in breeding strategy.Molecular breeding : new strategies in plant improvement · 2023Review
- Lemon grass essential oil improves Gladiolus grandiflorus postharvest life by modulating water relations, microbial growth, biochemical activity, and gene expression.Scientific reports · 2023Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock (HS) is a common form of stress suffered by plants. It has been proposed that calmodulin (CaM) is involved in HS signal transduction, but direct evidence has been lacking. To investigate the potential regulatory function of CaM in the HS signal transduction pathway, T-DNA knockout mutants for AtCaM2, AtCaM3, and AtCaM4 were obtained and their thermotolerance tested. Of the three knockout mutant plants, there were no differences compared with wild-type plants under normal conditions. However, the AtCaM3 knockout mutant showed a clear reduction in thermotolerance after heat treatment at 45 degrees C for 50 min. Overexpression of AtCaM3 in either the AtCaM3 knockout or wild-type background significantly rescued or increased the thermotolerance, respectively. Results from electrophoretic mobility-shift assays, real-time quantitative reverse transcription-polymerase chain reaction, and western-blot analyses revealed that, after HS, the DNA-binding activity of HS transcription factors, mRNA transcription of HS protein genes, and accumulation of HS protein were down-regulated in the AtCaM3 knockout mutant and up-regulated in the AtCaM3-overexpressing transgenic lines. Taken together, these results suggest that endogenous AtCaM3 is a key component in the Ca2+-CaM HS signal transduction pathway.
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