ArticleDevelopment (Cambridge, England)2009
MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Widespread association of Polycomb complex-deposited histone H2A monoubiquitylation with enhancers and neuronal gene regulation.Science advances · 2025Article
- RINGs, DUBs and Abnormal Brain Growth-Histone H2A Ubiquitination in Brain Development and Disease.Epigenomes · 2022Review
- Article
- PRC1 chromatin factors strengthen the consistency of neuronal cell fate specification and maintenance in C. elegans.PLoS genetics · 2022Article
- The regulatory landscape of neurite development inFrontiers in molecular neuroscience · 2022Review
- Comparative Epigenomics Reveals that RNA Polymerase II Pausing and Chromatin Domain Organization Control Nematode piRNA Biogenesis.Developmental cell · 2019Article
- Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality inGenetics · 2018Article
- De novo mutation inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- ZRF1 mediates remodeling of E3 ligases at DNA lesion sites during nucleotide excision repair.The Journal of cell biology · 2016Article
- Transcriptional regulation of gene expression in C. elegans.WormBook : the online review of C. elegans biology · 2013Review
- Sticky situations: recent advances in control of cell adhesion during neuronal migration.Current opinion in neurobiology · 2012Review
- Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.Science (New York, N.Y.) · 2010Article
- O-GlcNAc cycling: emerging roles in development and epigenetics.Seminars in cell & developmental biology · 2010Review
- Mechanisms of polycomb gene silencing: knowns and unknowns.Nature reviews. Molecular cell biology · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Polycomb repression complex 2 (PRC2) methylates histone H3 lysine 27 at target genes to modify gene expression, and this mark is recognized by PRC1, which ubiquitylates histone H2A. In Caenorhabditis elegans, a complex of the MES-2, MES-3 and MES-6 proteins is functionally analogous to the PRC2 complex, but the functional analog of PRC1, and indeed whether C. elegans has such a complex, has been unclear. We describe here that MIG-32 and SPAT-3A are functional analogs of PRC1 in C. elegans, where they are required for neuronal migrations and during vulval development. mig-32 and spat-3 mutants are defective in H2A ubiquitylation, and have nervous system defects that partially overlap with those of mes mutants. However, unlike the mes mutants, mig-32 and spat-3 mutants are fertile, suggesting that PRC1 function is not absolutely required in the germline for essential functions of PRC2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.