ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2009
Melatonin and tryptophan affect the activity-rest rhythm, core and peripheral temperatures, and interleukin levels in the ringdove: changes with age.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers.Nutrition journal · 2014Trial
- A Jerte valley cherry product provides beneficial effects on sleep quality. Influence on aging.The journal of nutrition, health & aging · 2013Trial
- Exogenous Melatonin as a Sleep-promoting Agent beyond its Chronobiotic Properties: A Scoping Review of its Effects on Key Sleep-wake Neurotransmitters.Current neuropharmacology · 2026Article
- The Role of Melatonin to Ameliorate Oxidative Stress in Sperm Cells.International journal of molecular sciences · 2023Review
- Sleeping Disorders in Healthy Individuals with Different Dietary Patterns and BMI, Questionnaire Assessment.International journal of environmental research and public health · 2021Article
- Effects of Sleep Deprivation on the Tryptophan Metabolism.International journal of tryptophan research : IJTR · 2020Review
- The Potential of Phytomelatonin as a Nutraceutical.Molecules (Basel, Switzerland) · 2018Review
- Reproducibility and Temporal Structure in Weekly Resting-State fMRI over a Period of 3.5 Years.PloS one · 2015Article
- Optimization of L-Tryptophan Biosynthesis From L-Serine of Processed Iranian Beet and Cane Molasses and Indole by Induced Escherichia coli ATCC 11303 Cells.Jundishapur journal of microbiology · 2014Article
- Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans.Age (Dordrecht, Netherlands) · 2013Article
- Increased mortality in a colony of zebra finches exposed to continuous light.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
- Chrononutrition against oxidative stress in aging.Oxidative medicine and cellular longevity · 2013Review
- Systemic inflammatory load in young and old ringdoves is modulated by consumption of a Jerte Valley cherry-based product.Journal of medicinal food · 2012Article
- Oxidative stress and immunosenescence: therapeutic effects of melatonin.Oxidative medicine and cellular longevity · 2012Review
- A jerte valley cherry-based product as a supply of tryptophan.International journal of tryptophan research : IJTR · 2012Article
- Melatonin and tryptophan counteract lipid peroxidation and modulate superoxide dismutase activity in ringdove heterophils in vivo. Effect of antigen-induced activation and age.Age (Dordrecht, Netherlands) · 2009Article
- Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function: Streptopelia Risoria as a Model.International journal of tryptophan research : IJTR · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is known to alter the circadian rhythms of melatonin, serotonin, thermoregulatory responses, cytokine production, and sleep/wakefulness which affect sleep quality. We tested the possible palliative effects of a 3-day administration of melatonin (0.25 or 2.5 mg/kg of body weight [b.w.] to young and old ringdoves, respectively) or tryptophan (300 mg/kg of b.w. to old ringdoves) on these rhythms. Doves are a monophasic, diurnal species; these characteristics are similar in humans. Old animals presented lower melatonin and serotonin levels; higher interleukin (IL)-1beta, IL-6, and tumor necrosis factor alpha values; and reductions in the Midline-Estimating Statistic of Rhythm and amplitude of activity-rest rhythm and in the amplitude of the core temperature rhythm. Melatonin raised serum melatonin levels; tryptophan increased both melatonin and serotonin levels. Melatonin and tryptophan lowered nocturnal activity, core temperature, and cytokine levels and increased peripheral temperature in both groups. Melatonin or tryptophan may limit or reverse some of the changes that occur in sleep-wake rhythms and temperature due to age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.