ArticleGenome research2009
MtDNA mutation pattern in tumors and human evolution are shaped by similar selective constraints.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Genotype-specific precision tumor therapy using mitochondrial DNA mutation-induced drug release system.Science advances · 2023Article
- Mitochondrial DNA is a major source of driver mutations in cancer.Trends in cancer · 2022Review
- Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations.Journal of experimental & clinical cancer research : CR · 2017Article
- The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities.Frontiers in oncology · 2017Review
- Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data.Genome biology · 2016Article
- Global human frequencies of predicted nuclear pathogenic variants and the role played by protein hydrophobicity in pathogenicity potential.Scientific reports · 2014Article
- Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?Nature reviews. Cancer · 2014Review
- Mutational patterns in the breast cancer mitochondrial genome, with clinical correlates.Carcinogenesis · 2014Article
- Functional recurrent mutations in the human mitochondrial phylogeny: dual roles in evolution and disease.Genome biology and evolution · 2013Article
- Mitochondrial DNA heteroplasmy in diabetes and normal adults: role of acquired and inherited mutational patterns in twins.Human molecular genetics · 2012Article
- Review
- Early evolution without a tree of life.Biology direct · 2011Review
- Plastids, genomes, and the probability of gene transfer.Genome biology and evolution · 2011Article
- Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes.American journal of human genetics · 2010Article
- The impact of darwinian evolution on medicine: the maternal side of the story.Rambam Maimonides medical journal · 2010Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple human mutational landscapes of normal and cancer conditions are currently available. However, while the unique mutational patterns of tumors have been extensively studied, little attention has been paid to similarities between malignant and normal conditions. Here we compared the pattern of mutations in the mitochondrial genomes (mtDNAs) of cancer (98 sequences) and natural populations (2400 sequences). De novo mtDNA mutations in cancer preferentially colocalized with ancient variants in human phylogeny. A significant portion of the cancer mutations was organized in recurrent combinations (COMs), reaching a length of seven mutations, which also colocalized with ancient variants. Thus, by analyzing similarities rather than differences in patterns of mtDNA mutations in tumor and human evolution, we discovered evidence for similar selective constraints, suggesting a functional potential for these mutations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.