ReviewCurrent allergy and asthma reports2009
Acetaminophen use: a risk for asthma?
Review in Current allergy and asthma reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials.BMC pulmonary medicine · 2020Pooled it
- [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management].Schmerz (Berlin, Germany) · 2014Guideline
- A Single Early-Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung.American journal of respiratory cell and molecular biology · 2025Article
- Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures.American journal of physiology. Lung cellular and molecular physiology · 2022Review
- Pulmonary implications of acetaminophen exposures independent of hepatic toxicity.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Article
- Long-term adverse effects of paracetamol - a review.British journal of clinical pharmacology · 2018Review
- Pattern of Self Prescribed Analgesic Use in a Rural Area of Delhi: Exploring the Potential Role of Internet.Journal of clinical and diagnostic research : JCDR · 2017Article
- Safety issues of current analgesics: an update.Clujul medical (1957) · 2015Review
- Causal assessment of pharmaceutical treatments: why standards of evidence should not be the same for benefits and harms?Drug safety · 2015Article
- Safety vs. efficacy assessment of pharmaceuticals: Epistemological rationales and methods.Preventive medicine reports · 2014Article
- Prescription-acquired acetaminophen use and the risk of asthma in adults: a case-control study.The Annals of pharmacotherapy · 2012Article
- Effects of Acetaminophen consumption in asthmatic children.Iranian Red Crescent medical journal · 2012Article
- Knowledge, attitudes and misconceptions of primary care physicians regarding fever in children: a cross sectional study.Italian journal of pediatrics · 2012Article
- Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study.World journal of gastroenterology · 2012Article
- Implementation of a standardized pain management in a pediatric surgery unit.Pediatric surgery international · 2010Review
- Similarities in features of autism and asthma and a possible link to acetaminophen use.Medical hypotheses · 2010Article
- Prenatal exposure to acetaminophen and asthma in children.Obstetrics and gynecology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing number of studies show that regular use of acetaminophen (paracetamol) carries a dose-dependent risk of developing allergies in general and asthma in particular and of worsening other respiratory diseases and lung function. The most disturbing finding has come from the population-based Avon Longitudinal Study of Parents and Children, in which use of paracetamol-but not aspirin-in late pregnancy was positively associated with asthma when comparing children whose mothers took paracetamol "sometimes" and "most days/daily" with those whose mothers never took it. Assuming a causal relationship, the percentage of asthma attributable to paracetamol use in late pregnancy was 7%. In this review, we present data from the most important studies published since 2000. Although the pathophysiology remains unclear, the available data justify a warning to the general public that the uncritical use of over-the-counter acetaminophen can lead to the development of allergies and asthma, even in utero.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.