ArticleBMC developmental biology2009
Trichostatin A treatment of cloned mouse embryos improves constitutive heterochromatin remodeling as well as developmental potential to term.
Article in BMC developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 89 citations in OpenAlex.
- Genome-wide methylome pattern predictive network analysis reveal mesenchymal stem cell's propensity to undergo cardiovascular lineage.3 Biotech · 2022Article
- Cardiac Differentiation of Mesenchymal Stem Cells: Impact of Biological and Chemical Inducers.Stem cell reviews and reports · 2021Review
- SUMOylated PRC1 controls histone H3.3 deposition and genome integrity of embryonic heterochromatin.The EMBO journal · 2020Article
- Epigenetics and precision medicine in cardiovascular patients: from basic concepts to the clinical arena.European heart journal · 2018Review
- Three-dimensional analysis of nuclear heterochromatin distribution during early development in the rabbit.Chromosoma · 2018Article
- Cytoplasmic volume of recipient oocytes affects the nucleus reprogramming and the developmental competence of HMC buffalo (Bubalus bubalis) embryos.The Journal of veterinary medical science · 2018Article
- Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes.Cell reports · 2018Article
- Dynamics of post-translationally modified histones during barley pollen embryogenesis in the presence or absence of the epi-drug trichostatin A.Plant reproduction · 2017Article
- Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules.Biology open · 2017Article
- DOT1L inhibitor improves early development of porcine somatic cell nuclear transfer embryos.PloS one · 2017Article
- Techniques of Human Embryonic Stem Cell and Induced Pluripotent Stem Cell Derivation.Archivum immunologiae et therapiae experimentalis · 2016Review
- Article
- Cell-free extract from porcine induced pluripotent stem cells can affect porcine somatic cell nuclear reprogramming.The Journal of reproduction and development · 2015Article
- Improved development of somatic cell cloned mouse embryos by vitamin C and latrunculin A.PloS one · 2015Article
- Telomere elongation facilitated by trichostatin a in cloned embryos and pigs by somatic cell nuclear transfer.Stem cell reviews and reports · 2014Article
- Article
- Inhibition of histone deacetylases enhances DNA damage repair in SCNT embryos.Cell cycle (Georgetown, Tex.) · 2014Article
- Histone deacetylase inhibitor improves the development and acetylation levels of cat-cow interspecies cloned embryos.Cellular reprogramming · 2013Article
- Synergistic effect of trichostatin A and scriptaid on the development of cloned rabbit embryos.Theriogenology · 2013Article
- Valproic acid treatment from the 4-cell stage improves Oct4 expression and nuclear distribution of histone H3K27me3 in mouse cloned blastocysts.The Journal of reproduction and development · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenome reprogramming in early mouse embryos is associated with nuclear reorganization and particular features such as the peculiar distribution of centromeric and pericentric heterochromatin during the first developmental stage. This zygote-specific heterochromatin organization could be observed both in maternal and paternal pronuclei after natural fertilization as well as in embryonic stem (ES) cell nuclei after nuclear transfer suggesting that this particular type of nuclear organization was essential for embryonic reprogramming and subsequent development.
resultsHere, we show that remodeling into a zygotic-like organization also occurs after somatic cell nuclear transfer (SCNT), supporting the hypothesis that reorganization of constitutive heterochromatin occurs regardless of the source and differentiation state of the starting material. However, abnormal nuclear remodeling was frequently observed after SCNT, in association with low developmental efficiency. When transient treatment with the histone deacetylase inhibitor trichostatin A (TSA) was tested, we observed improved nuclear remodeling in 1-cell SCNT embryos that correlated with improved rates of embryonic development at subsequent stages.
conclusionTogether, the results suggest that proper organization of constitutive heterochromatin in early embryos is involved in the initial developmental steps and might have long term consequences, especially in cloning procedures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.