ArticleGenome biology2009
High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research.
Article in Genome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 99 citations in OpenAlex.
- Resolving repetitive and telomeric regions through a high-contiguity genome assembly of the African Turquoise killifish.Genes & genomics · 2026Article
- A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging.bioRxiv : the preprint server for biology · 2026Article
- Multiple Origins of Sex Chromosomes in Nothobranchius Killifishes.Molecular ecology · 2025Article
- The genome of the MZM-0403 strain of the African turquoise killifish, Nothobranchius furzeri.G3 (Bethesda, Md.) · 2025Article
- Convergent gene losses and pseudogenizations in multiple lineages of stomachless fishes.Communications biology · 2024Article
- Fast satellite DNA evolution in Nothobranchius annual killifishes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Article
- Widespread sex dimorphism across single-cell transcriptomes of adult African turquoise killifish tissues.Cell reports · 2023Article
- Dietary intake of microplastics impairs digestive performance, induces hepatic dysfunction, and shortens lifespan in the annual fish Nothobranchius guentheri.Biogerontology · 2023Article
- Karyotype differentiation in theComparative cytogenetics · 2023Article
- Partial sex linkage and linkage disequilibrium on the guppy sex chromosome.Molecular ecology · 2022Article
- Administration of krill oil extends lifespan of fish Nothobranchius guentheri via enhancement of antioxidant system and suppression of NF-κB pathway.Fish physiology and biochemistry · 2022Article
- Dietary intake of diosgenin delays aging of male fish Nothobranchius guentheri through modulation of multiple pathways that play prominent roles in ROS production.Biogerontology · 2022Article
- The Effect of Meclofenoxate on the Transcriptome of Aging Brain ofInternational journal of molecular sciences · 2022Article
- Living in Temporary Ponds Loading Giant Genomes: The Neotropical Annual Killifish GenusFrontiers in genetics · 2022Review
- Rare genetic coding variants associated with human longevity and protection against age-related diseases.Nature aging · 2021Article
- A high-quality de novo genome assembly of one swamp eel (Monopterus albus) strain with PacBio and Hi-C sequencing data.G3 (Bethesda, Md.) · 2021Article
- Age-Dependent Regulation of Notch Family Members in the Neuronal Stem Cell Niches of the Short-Lived KillifishFrontiers in cell and developmental biology · 2021Article
- Article
- Review
- The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development.BMC genomics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe annual fish Nothobranchius furzeri is the vertebrate with the shortest known life span in captivity. Fish of the GRZ strain live only three to four months under optimal laboratory conditions, show explosive growth, early sexual maturation and age-dependent physiological and behavioral decline, and express aging related biomarkers. Treatment with resveratrol and low temperature significantly extends the maximum life span. These features make N. furzeri a promising new vertebrate model for age research.
resultsTo contribute to establishing N. furzeri as a new model organism, we provide a first insight into its genome and a comparison to medaka, stickleback, tetraodon and zebrafish. The N. furzeri genome contains 19 chromosomes (2n = 38). Its genome of between 1.6 and 1.9 Gb is the largest among the analyzed fish species and has, at 45%, the highest repeat content. Remarkably, tandem repeats comprise 21%, which is 4-12 times more than in the other four fish species. In addition, G+C-rich tandem repeats preferentially localize to centromeric regions. Phylogenetic analysis based on coding sequences identifies medaka as the closest relative. Genotyping of an initial set of 27 markers and multi-locus fingerprinting of one microsatellite provides the first molecular evidence that the GRZ strain is highly inbred.
conclusionsOur work presents a first basis for systematic genomic and genetic analyses aimed at understanding the mechanisms of life span determination in N. furzeri.
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