ArticleBMC developmental biology2009
Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous system.
Article in BMC developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain.GeroScience · 2022Article
- A spatially aware likelihood test to detect sweeps from haplotype distributions.PLoS genetics · 2022Article
- Identification of Hub Genes in Colorectal Adenocarcinoma by Integrated Bioinformatics.Frontiers in cell and developmental biology · 2022Article
- Expression of the CLCA4 Gene in Esophageal Carcinoma and Its Impact on the Biologic Function of Esophageal Carcinoma Cells.Journal of oncology · 2021Article
- Downregulation of CLCA4 expression is associated with the development and progression of colorectal cancer.Oncology letters · 2020Article
- CALD1, CNN1, and TAGLN identified as potential prognostic molecular markers of bladder cancer by bioinformatics analysis.Medicine · 2019Article
- Article
- Exploring evidence of positive selection signatures in cattle breeds selected for different traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- CLCA4 inhibits bladder cancer cell proliferation, migration, and invasion by suppressing the PI3K/AKT pathway.Oncotarget · 2017Article
- Ion transporter NKCC1, modulator of neurogenesis in murine olfactory neurons.The Journal of biological chemistry · 2015Article
- Article
- Ca2+-activated Cl- channels of the ClCa family express in the cilia of a subset of rat olfactory sensory neurons.PloS one · 2013Article
- Gene-expression analysis of early- and late-maturation-stage rat enamel organ.European journal of oral sciences · 2011Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMembers of the calcium-activated chloride channel (CLCA) gene family have been suggested to possess a variety of functions including cell adhesion and tumor suppression. Expression of CLCA family members has mostly been analyzed in non-neural tissues. Here we describe the expression of mouse and human CLCA genes in the nervous system.
resultsWe show that from the six mouse CLCA family members only Clca1, Clca2 and Clca4 mRNAs are expressed in the adult brain, predominantly in olfactory ensheathing cells. During mouse nervous system development Clca1/2 is more widely expressed, particularly in cranial nerves, the diencephalon and in the cerebral cortex. While human CLCA2 and CLCA4 genes are widely expressed in brain, and at particularly high levels in the optic nerve, human CLCA3, the closest homologue of mouse Clca1, Clca2 and Clca4, is not expressed in the brain. Furthermore, we characterize the expression pattern of mouse Clca1/2 genes during embryonic development by in situ hybridization.
conclusionThe data published in this article indicate that within the nervous system mouse Clca1/2 genes are highly expressed in the cells ensheathing cranial nerves. Human CLCA2 and CLCA4 mRNAs are expressed at high level in optic nerve. High level expression of CLCA family members in mouse and human glial cells ensheathing nerves suggests a specific role for CLCA proteins in the development and homeostasis of these cells.
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