ArticleBritish journal of pharmacology2009
Neutrophils contribute to intracerebral haemorrhages after treatment with recombinant tissue plasminogen activator following cerebral ischaemia.
Article in British journal of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 66 citations in OpenAlex.
- Associations of plasma MMP-9 and MPO with functional outcome in moderate to severe acute ischemic stroke.Scientific reports · 2026Article
- The association between variation of neutrophil-to-lymphocyte ratio and post-thrombolysis early neurological outcomes in patients with stroke of different TOAST classification.Scientific reports · 2025Article
- Net water uptake combined with neutrophil-to-lymphocyte ratio predictive value after successful recanalization in acute large vessel occlusion stroke.Frontiers in neurology · 2025Article
- Association of Systemic Inflammation Indexes with 90-Day Functional Outcomes in Acute Ischemic Stroke Patients Undergoing Intravenous Thrombolysis.International journal of general medicine · 2025Article
- Article
- Identification of immune-related biomarkers for intracerebral hemorrhage diagnosis based on RNA sequencing and machine learning.Frontiers in immunology · 2024Article
- The role of neutrophils in tPA thrombolysis after stroke: a malicious troublemaker.Frontiers in immunology · 2024Review
- The SONFrontiers in neurology · 2022Article
- Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke.Blood · 2021Article
- Damage to the blood‑brain barrier and activation of neuroinflammation by focal cerebral ischemia under hyperglycemic condition.International journal of molecular medicine · 2021Article
- Article
- The Protective Role of Immunomodulators on Tissue-Type Plasminogen Activator-Induced Hemorrhagic Transformation in Experimental Stroke: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2020Article
- Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke.ACS nano · 2019Article
- CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage.Acta neuropathologica communications · 2018Article
- Neutrophil-To-Lymphocyte Ratio Predicts 3-Month Outcome of Acute Ischemic Stroke.Neurotoxicity research · 2017Article
- Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke.Circulation research · 2017Review
- Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke.Journal of neuroinflammation · 2016Article
- Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke.Frontiers in cellular neuroscience · 2016Review
- Experimental animal models and inflammatory cellular changes in cerebral ischemic and hemorrhagic stroke.Neuroscience bulletin · 2015Review
- Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischaemia.British journal of pharmacology · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePolymorphonuclear neutrophils (PMNs) contribute to the vascular damage caused by transient cerebral ischaemia. Here we have evaluated the role of PMNs in intracerebral haemorrhage (ICH) induced in a model of thrombolysis with recombinant tissue plasminogen activator (t-PA) during the acute phase of cerebral ischaemia. EXPERIMENTAL APPROACH: The middle cerebral artery (MCA) of male spontaneously hypertensive rats was occluded for 1 h followed by reperfusion and, 5 h later, infusion of thrombolytic products (generated in vitro by t-PA on autologous clots). Effects of pretreatment (before the MCA occlusion) with vinblastine (4 days before; 0.5 mg.kg(-1)), monoclonal anti-neutrophil antibody (mAbRP3; 12 h, 0.3 mg.kg(-1)) or saline on ICH, neutrophil infiltration, MCA vascular reactivity and brain infarct volume were assessed, 24 h after the beginning of reperfusion. KEY
resultsDepletion of circulating neutrophils significantly reduced t-PA-induced ICH (vinblastine, 4.6 +/- 1.0; mAbRP3, 5.2 +/- 1.0 vs. saline, 10.8 +/- 2.7 haemorrhages; P < 0.05). This depletion was associated with a decrease in cerebral infiltration by neutrophils and a decrease of endothelium-dependent, vascular dysfunction in isolated MCA, induced by the ischaemia/reperfusion and t-PA treatment. Brain infarct volume was significantly decreased after vinblastine treatment (159 +/- 13 mm(3) vs. 243 +/- 16 mm(3) with saline; P < 0.01) but not after depletion with mAbRP3 (221 +/- 22 mm(3)). CONCLUSIONS AND IMPLICATIONS: Our results showed that pharmacological depletion of PMNs prevented t-PA-induced ICH, in parallel with a decrease in cerebral infiltration by PMNs and a decreased endothelial dysfunction in cerebral blood vessels.
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