Evidence map›Paper›PMID 19210230›Full record

ArticleViral immunology2009

gamma-Herpesvirus-induced protection against bacterial infection is transient.

Eric J Yager, Frank M Szaba, Larry W Kummer, Kathleen G Lanzer, Claire E Burkum, Stephen T Smiley, Marcia A Blackman

Open access · greenAbstract read
In one paragraph

Article in Viral immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 59 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
  6. Control of B Cell Lymphoma by Gammaherpesvirus-Induced Memory CD8 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Invasions of Host-Associated Microbiome Networks.Advances in ecological research · 2017
    Article
  14. Article
  15. Review
  16. T cell responses to cytomegalovirus.Nature reviews. Immunology · 2016
    Review
  17. Review
  18. Article
  19. Article
  20. Infectious mononucleosis.Clinical & translational immunology · 2015
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Eric J YagerTrudeau Institute, Saranac Lake, New York 12983, USA.
Frank M Szaba
Larry W Kummer
Kathleen G Lanzer
Claire E Burkum
Stephen T Smiley
Marcia A Blackman
Trudeau Institute · US

Funding

MOLECULAR BIOLOGY COREP01AG021600 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HAYNES, LAURA · 2003 to 2016
$24.4M
Cell-mediated protection against pneumonic plagueR01AI061577 · NIAID · TRUDEAU INSTITUTE, INC. · PI LIN, JR-SHIUAN · 2004 to 2013
$3.8M
T CELL IMMUNITY TO MHV 68, A MURINE GAMMA HERPEVIRUSR01AI042927 · NIAID · TRUDEAU INSTITUTE, INC. · PI BLACKMAN, MARCIA A · 1998 to 2008
$2.5M
Immune control of latent gammaherpesvirus infectionR01AI051602 · NIAID · TRUDEAU INSTITUTE, INC. · PI BLACKMAN, MARCIA A · 2003 to 2007
$1.9M
Cell-mediated protection against pneumonic plagueR56AI061577 · NIAID · TRUDEAU INSTITUTE, INC. · PI SMILEY, STEPHEN T · 2008 to 2008
$492k
NIAID NIH HHS AI42927NIAID NIH HHS AI51602NIAID NIH HHS AI61577NIA NIH HHS AG21600
6 · The paper itself

Abstract

Herpesviruses are widely disseminated in the population and establish lifelong latency, which is associated with a variety of pathological consequences. A recent report showed that mice latently infected with either murine gamma-herpesvirus-68 (gammaHV68) or murine cytomegalovirus (mCMV), mouse pathogens genetically similar to the human herpesviruses, Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and cytomegalovirus, had enhanced resistance to subsequent bacterial infection, suggesting protective as well as deleterious effects of latency. Here we confirm that latent gammaHV68 infection confers protection against subsequent infection with Listeria monocytogenes. However, the effect is transient, lasting only a few months.

Indexed as

Virus Latency3T3 CellsAnimalsFemaleGammaherpesvirinaeHerpesviridae InfectionsListeria monocytogenesListeriosisMiceMice, Inbred C57BLRhadinovirus

Identifiers

PMID19210230
PMCPMC2952138
OpenAlexW1988969261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.