ReviewJournal of natural products2009
A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products.
Review in Journal of natural products, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria.Marine drugs · 2022Review
- Molecular genomic features associated with in vitro response of the NCI-60 cancer cell line panel to natural products.Molecular oncology · 2021Article
- Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8ACS medicinal chemistry letters · 2020Article
- Increasing Metabolic Diversity in Marine Sponges Extracts by Controlling Extraction Parameters.Marine drugs · 2018Article
- The Bengamides: A Mini-Review of Natural Sources, Analogues, Biological Properties, Biosynthetic Origins, and Future Prospects.Journal of natural products · 2017Review
- Application of diffusion growth chambers for the cultivation of marine sponge-associated bacteria.Marine biotechnology (New York, N.Y.) · 2014Article
- Chemistry and biology of bengamides and bengazoles, bioactive natural products from Jaspis sponges.Marine drugs · 2014Review
- Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells.BMC complementary and alternative medicine · 2012Article
- Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole.Marine drugs · 2012Article
- Lessons from the past and charting the future of marine natural products drug discovery and chemical biology.Chemistry & biology · 2012Review
- Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants.Bioorganic & medicinal chemistry · 2011Review
- Medicinal chemistry for 2020.Future medicinal chemistry · 2011Article
- The relevance of higher plants in lead compound discovery programs.Journal of natural products · 2011Review
- Stachylines A-D from the sponge-derived fungus Stachylidium sp.Journal of natural products · 2011Article
- The marine sponge metabolite mycothiazole: a novel prototype mitochondrial complex I inhibitor.Bioorganic & medicinal chemistry · 2010Article
- Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide.Marine drugs · 2010Review
- The continuing search for antitumor agents from higher plants.Phytochemistry letters · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Marine natural products continue to be a source of significant molecular structures that serve as a stimulus to seed further significant research. This account reviews some of the major advances in the study of marine biomolecules made at UC Santa Cruz over more than three decades. The continuing challenge of discovery and characterization of what we term "inspirational molecular structures" will be presented in a comprehensive fashion. Examples of privileged molecular structures and their impact on biomedicinal research will be an important theme. The three major groups of organisms explored include seaweeds, sponges, and marine-derived fungi, and the study of their active principles has greatly benefited from synergistic collaborations with both academic and biopharmaceutical groups. The concluding sections of this chronicle will touch on prospects for future outcomes involving new sources and strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.