ArticlePacific Symposium on Biocomputing. Pacific Symposium on Biocomputing2009
Inferring genome-wide mosaic structure.
Article in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- The genome architecture of the Collaborative Cross mouse genetic reference population.Genetics · 2012Article
- Accelerating the inbreeding of multi-parental recombinant inbred lines generated by sibling matings.G3 (Bethesda, Md.) · 2012Article
- Genome-wide compatible SNP intervals and their properties.The 2010 ACM International Conference on Bioinformatics and Computational Biology : ACM-BCB 2010 : Niagara Falls, New York, U.S.A., August 2-4, 2010. ACM International Conference on Bioinformatics and Computational Biology (1st : 2010 :... · 2010Article
- Efficient genome ancestry inference in complex pedigrees with inbreeding.Bioinformatics (Oxford, England) · 2010Article
- Replication and narrowing of gene expression quantitative trait loci using inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Inferring genome-wide mosaic structure.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Genetic recombination plays two essential biological roles. It ensures the fidelity of the transmission of genetic information from one generation to the next and it generates new combinations of genetic variants. Therefore, recombination is a critical process in shaping arrangement of polymorphisms within populations. "Recombination breakpoints" in a given set of genomes from individuals in a population divide the genome into haplotype blocks, resulting in a mosaic structure on the genome. In this paper, we study the Minimum Mosaic Problem: given a set of genome sequences from individuals within a population, compute a mosaic structure containing the minimum number of breakpoints. This mosaic structure provides a good estimation of the minimum number of recombination events (and their location) required to generate the existing haplotypes in the population. We solve this problem by finding the shortest path in a directed graph. Our algorithm's efficiency permits genome-wide analysis.
Indexed as
Identifiers
19209700PMC2736068W1987704665What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.