ArticleJournal of neurochemistry2009
Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation.
Article in Journal of neurochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons.Autonomic neuroscience : basic & clinical · 2023Article
- Cholesterol Management in Neurology: Time for Revised Strategies?Journal of personalized medicine · 2022Review
- Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1 to the plasma membrane.PLoS pathogens · 2021Article
- Review
- Protein expression of prenyltransferase subunits in postmortem schizophrenia dorsolateral prefrontal cortex.Translational psychiatry · 2020Article
- MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons.Cellular and molecular neurobiology · 2019Article
- ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway.Neurobiology of disease · 2018Article
- Modulation of Ion Channels in the Superior Cervical Ganglion Neurons by Myocardial Ischemia and Fluvastatin Treatment.Frontiers in physiology · 2018Article
- MACF1 Controls Migration and Positioning of Cortical GABAergic Interneurons in Mice.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo.Nature communications · 2017Article
- MTOR controls genesis and autophagy of GABAergic interneurons during brain development.Autophagy · 2017Article
- Microtubule-Actin Crosslinking Factor 1 Is Required for Dendritic Arborization and Axon Outgrowth in the Developing Brain.Molecular neurobiology · 2016Article
- Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons.Cell death & disease · 2016Article
- BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling.Developmental neurobiology · 2016Article
- Simvastatin inhibits protein isoprenylation in the brain.Neuroscience · 2016Article
- Loss of GSK-3 Causes Abnormal Astrogenesis and Behavior in Mice.Molecular neurobiology · 2016Article
- Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants.Stem cells translational medicine · 2016Article
- Essential Roles for ARID1B in Dendritic Arborization and Spine Morphology of Developing Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Molecular Mechanisms of Sympathetic Remodeling and Arrhythmias.Circulation. Arrhythmia and electrophysiology · 2016Review
- Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons.Molecular and cellular neurosciences · 2015Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Clinical and experimental evidence suggest that statins decrease sympathetic activity, but whether peripheral mechanisms involving direct actions on post-ganglionic sympathetic neurons contribute to this effect is not known. Because tonic activity of these neurons is directly correlated with the size of their dendritic arbor, we tested the hypothesis that statins decrease dendritic arborization in sympathetic neurons. Oral administration of atorvastatin (20 mg/kg/day for 7 days) significantly reduced dendritic arborization in vivo in sympathetic ganglia of adult male rats. In cultured sympathetic neurons, statins caused dendrite retraction and reversibly blocked bone morphogenetic protein-induced dendritic growth without altering cell survival or axonal growth. Supplementation with mevalonate or isoprenoids, but not cholesterol, attenuated the inhibitory effects of statins on dendritic growth, whereas specific inhibition of isoprenoid synthesis mimicked these statin effects. Statins blocked RhoA translocation to the membrane, an event that requires isoprenylation, and constitutively active RhoA reversed statin effects on dendrites. These observations that statins decrease dendritic arborization in sympathetic neurons by blocking RhoA activation suggest a novel mechanism by which statins decrease sympathetic activity and protect against cardiovascular and cerebrovascular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.