ArticleJournal of molecular evolution2009
Comparative genomics of phylogenetically diverse unicellular eukaryotes provide new insights into the genetic basis for the evolution of the programmed cell death machinery.
Article in Journal of molecular evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Review
- The Evolution of the Hallmarks of Aging.Frontiers in genetics · 2021Review
- The Distribution of Genes Associated With Regulated Cell Death Is Decoupled From the Mitochondrial Phenotypes Within Unicellular Eukaryotic Hosts.Frontiers in cell and developmental biology · 2020Article
- Article
- Caspases in plants: metacaspase gene family in plant stress responses.Functional & integrative genomics · 2015Review
- Apoptosis-like cell death pathways in the unicellular parasite Toxoplasma gondii following treatment with apoptosis inducers and chemotherapeutic agents: a proof-of-concept study.Apoptosis : an international journal on programmed cell death · 2013Article
- The first suicides: a legacy inherited by parasitic protozoans from prokaryote ancestors.Parasites & vectors · 2013Review
- Article
- New types of metacaspases in phytoplankton reveal diverse origins of cell death proteases.Cell death & disease · 2013Article
- Mastoparan-induced programmed cell death in the unicellular alga Chlamydomonas reinhardtii.Annals of botany · 2013Article
- Variation in apoptosis mechanisms employed by malaria parasites: the roles of inducers, dose dependence and parasite stages.Malaria journal · 2012Article
- Experimental evolution of multicellularity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective.Frontiers in cellular and infection microbiology · 2012Review
- On Programmed Cell Death in Plasmodium falciparum: Status Quo.Journal of tropical medicine · 2012Article
- Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites.Parasites & vectors · 2011Review
- Plasmodium falciparum metacaspase PfMCA-1 triggers a z-VAD-fmk inhibitable protease to promote cell death.PloS one · 2011Article
- Impact of protozoan cell death on parasite-host interactions and pathogenesis.Parasites & vectors · 2010Article
- Cathepsin B-like and cell death in the unicellular human pathogen Leishmania.Cell death & disease · 2010Article
- Rotenone enhances the antifungal properties of staurosporine.Eukaryotic cell · 2010Article
- An overview of the introns-first theory.Journal of molecular evolution · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Programmed cell death (PCD) represents a significant component of normal growth and development in multicellular organisms. Recently, PCD-like processes have been reported in single-celled eukaryotes, implying that some components of the PCD machinery existed early in eukaryotic evolution. This study provides a comparative analysis of PCD-related sequences across more than 50 unicellular genera from four eukaryotic supergroups: Unikonts, Excavata, Chromalveolata, and Plantae. A complex set of PCD-related sequences that correspond to domains or proteins associated with all main functional classes--from ligands and receptors to executors of PCD--was found in many unicellular lineages. Several PCD domains and proteins previously thought to be restricted to animals or land plants are also present in unicellular species. Noteworthy, the yeast, Saccharomyces cerevisiae--used as an experimental model system for PCD research, has a rather reduced set of PCD-related sequences relative to other unicellular species. The phylogenetic distribution of the PCD-related sequences identified in unicellular lineages suggests that the genetic basis for the evolution of the complex PCD machinery present in extant multicellular lineages has been established early in the evolution of eukaryotes. The shaping of the PCD machinery in multicellular lineages involved the duplication, co-option, recruitment, and shuffling of domains already present in their unicellular ancestors.
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