ArticleTherapeutics and clinical risk management2008
Postoperative ileus: strategies for reduction.
Article in Therapeutics and clinical risk management, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02958566 (Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- The influence of diabetes on postoperative complications following colorectal surgery.Techniques in coloproctology · 2021Pooled it
- Pharmacological management to prevent ileus in major abdominal surgery: a systematic review and meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Pooled it
- Does caffeine enhance bowel recovery after elective colorectal resection? A prospective double-blinded randomized clinical trial.Techniques in coloproctology · 2021Trial
- A Double-Blinded Randomized Clinical Study on the Therapeutic Effect of Gastrografin in Prolonged Postoperative Ileus After Elective Colorectal Surgery.World journal of surgery · 2016Trial
- The Effects of Drinking Coffee While Recovering from Colon and Rectal Resection Surgery.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2015Trial
- Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients.International journal of colorectal disease · 2014Trial
- A comparative study of 'fast-track' versus traditional peri-operative care protocols in gastrointestinal surgeries.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Trial
- Decision-making in emergency colorectal surgery for cancer.Annals of medicine and surgery (2012) · 2026Article
- Biomarkers and immunomodulatory effect of erythropoietin in postoperative ileus.BMC research notes · 2026Article
- Underestimation of postoperative ileus as a benign complication in spine surgery: a case-control study in a major spine surgery centre in Saudi Arabia.Journal of spine surgery (Hong Kong) · 2025Article
- Postoperative ileus and associated factors in patients following major abdominal surgery in Ethiopia: a prospective cohort study.BMC surgery · 2025Article
- Article
- Fluid and electrolyte management: increasing the knowledge of House Officers using an interactive eLearning tool.Irish journal of medical science · 2023Article
- Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery.Experimental and therapeutic medicine · 2022Article
- Preoperative small bowel dilation is associated with ileus after right colectomy.Surgery in practice and science · 2022Article
- Review
- Altered Intestinal Permeability and Drug Repositioning in a Post-operative Ileus Guinea Pig Model.Journal of neurogastroenterology and motility · 2021Article
- Surgical Drains After Laparoscopic Donor Nephrectomy: Needed or Not?Annals of transplantation · 2020Article
- Early Outcome of Enhanced Recovery Programs Versus Conventional Perioperative Care in Elective Open Left Side Colonic Carcinoma Surgery: Analysis of 80 Cases.Indian journal of surgical oncology · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative Ileus (POI) is a frequent, frustrating occurrence for patients and surgeons after abdominal surgery. Despite significant research investigating how to reduce this multi-factorial phenomenon, a single strategy has not been shown to reduce POI's significant effects on length of stay (LOS) and hospital costs. Perhaps the most significant cause of POI is the use of narcotics for analgesia. Strategies that target inflammation and pain reduction such as NSAID use, epidural analgesia, and laparoscopic techniques will reduce POI but are accompanied by a simultaneous reduction in opioid use. Pharmacologic means of stimulating gut motility have not shown a positive effect, and the routine use of nasogastric tubes only increases morbidity. Recent multi-site phase III trials with alvimopan, a peripherally acting mu-antagonist, have shown significant reductions in POI and LOS by 12 and 16 hours, respectively, by blunting the effects of narcotics on gut motility while sparing centrally mediated analgesia. Use of alvimopan, along with a multi-modal postoperative treatment plan involving early ambulation, feeding, and avoiding nasogastric tubes, will likely be the crux of POI treatment and prevention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.